KEGG   Mus musculus (mouse): 16438Help
Entry
16438             CDS       T01002                                 

Gene name
Itpr1, D6Pas2, Gm10429, IP3R_1, IP3R1, InsP3R, Ip3r, Itpr-1, P400, Pcp-1, Pcp1, insP3R1, opt, wblo
Definition
(RefSeq) inositol 1,4,5-trisphosphate receptor 1
  KO
K04958  inositol 1,4,5-triphosphate receptor type 1
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04070  Phosphatidylinositol signaling system
mmu04114  Oocyte meiosis
mmu04140  Autophagy - animal
mmu04210  Apoptosis
mmu04218  Cellular senescence
mmu04270  Vascular smooth muscle contraction
mmu04371  Apelin signaling pathway
mmu04540  Gap junction
mmu04611  Platelet activation
mmu04621  NOD-like receptor signaling pathway
mmu04625  C-type lectin receptor signaling pathway
mmu04713  Circadian entrainment
mmu04720  Long-term potentiation
mmu04723  Retrograde endocannabinoid signaling
mmu04724  Glutamatergic synapse
mmu04725  Cholinergic synapse
mmu04726  Serotonergic synapse
mmu04728  Dopaminergic synapse
mmu04730  Long-term depression
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04912  GnRH signaling pathway
mmu04915  Estrogen signaling pathway
mmu04918  Thyroid hormone synthesis
mmu04921  Oxytocin signaling pathway
mmu04922  Glucagon signaling pathway
mmu04924  Renin secretion
mmu04925  Aldosterone synthesis and secretion
mmu04927  Cortisol synthesis and secretion
mmu04928  Parathyroid hormone synthesis, secretion and action
mmu04934  Cushing syndrome
mmu04970  Salivary secretion
mmu04971  Gastric acid secretion
mmu04972  Pancreatic secretion
mmu05010  Alzheimer disease
mmu05016  Huntington disease
mmu05163  Human cytomegalovirus infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05170  Human immunodeficiency virus 1 infection
mmu05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    16438 (Itpr1)
   04020 Calcium signaling pathway
    16438 (Itpr1)
   04070 Phosphatidylinositol signaling system
    16438 (Itpr1)
   04022 cGMP-PKG signaling pathway
    16438 (Itpr1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    16438 (Itpr1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    16438 (Itpr1)
   04210 Apoptosis
    16438 (Itpr1)
   04218 Cellular senescence
    16438 (Itpr1)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    16438 (Itpr1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    16438 (Itpr1)
   04621 NOD-like receptor signaling pathway
    16438 (Itpr1)
   04625 C-type lectin receptor signaling pathway
    16438 (Itpr1)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    16438 (Itpr1)
   04912 GnRH signaling pathway
    16438 (Itpr1)
   04915 Estrogen signaling pathway
    16438 (Itpr1)
   04921 Oxytocin signaling pathway
    16438 (Itpr1)
   04918 Thyroid hormone synthesis
    16438 (Itpr1)
   04928 Parathyroid hormone synthesis, secretion and action
    16438 (Itpr1)
   04924 Renin secretion
    16438 (Itpr1)
   04925 Aldosterone synthesis and secretion
    16438 (Itpr1)
   04927 Cortisol synthesis and secretion
    16438 (Itpr1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    16438 (Itpr1)
  09154 Digestive system
   04970 Salivary secretion
    16438 (Itpr1)
   04971 Gastric acid secretion
    16438 (Itpr1)
   04972 Pancreatic secretion
    16438 (Itpr1)
  09156 Nervous system
   04724 Glutamatergic synapse
    16438 (Itpr1)
   04725 Cholinergic synapse
    16438 (Itpr1)
   04728 Dopaminergic synapse
    16438 (Itpr1)
   04726 Serotonergic synapse
    16438 (Itpr1)
   04720 Long-term potentiation
    16438 (Itpr1)
   04730 Long-term depression
    16438 (Itpr1)
   04723 Retrograde endocannabinoid signaling
    16438 (Itpr1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    16438 (Itpr1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    16438 (Itpr1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    16438 (Itpr1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    16438 (Itpr1)
   05016 Huntington disease
    16438 (Itpr1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    16438 (Itpr1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    16438 (Itpr1)
   05163 Human cytomegalovirus infection
    16438 (Itpr1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    16438 (Itpr1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:mmu01009]
    16438 (Itpr1)
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:mmu04040]
    16438 (Itpr1)
Protein phosphatases and associated proteins [BR:mmu01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     16438 (Itpr1)
Ion channels [BR:mmu04040]
 Ligand-gated channels
  IP3 receptor
   16438 (Itpr1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ins145_P3_rec RYDR_ITPR MIR RIH_assoc Ion_trans
Motif
Other DBs
NCBI-GeneID: 16438
NCBI-ProteinID: NP_034715
MGI: 96623
Ensembl: ENSMUSG00000030102
Vega: OTTMUSG00000056439
UniProt: P11881 Q8C8N0 Q8BQN0 Q3UVA1 Q8C7X9
LinkDB All DBs
Structure
PDB: 

Position
6 E1; 6 49.74 cM
AA seq 2749 aa AA seqDB search
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKL
CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV
IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD
KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV
RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN
SLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPE
GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT
SPLKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL
VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE
LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH
NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT
NADILIETKLVLSRFEFEGVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAK
EGQKEDRDILSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRAS
FCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGTSKDEIKERFAQTMEFV
EEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHV
TTIFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEP
EKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETSSGNSSQEG
PSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGAL
QLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPD
EPMDGASGENEHKKTEEGTSKPLKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQ
QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN
LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEG
KFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVEL
LAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEI
YTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTT
LQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNN
LFLKSHNIVQKTALNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQA
ELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLRE
MMTKDRGYGEKQISIDESENAELPQAPEAENSTEQELEPSPPLRQLEDHKRGEALRQILV
NRYYGNIRPSGRRESLTSFGNGPLSPGGPSKPGGGGGGPGSSSTSRGEMSLAEVQCHLDK
EGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFY
DRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVRDQLLEASA
ATRKAFTTFRREADPDDHYQSGEGTQATTDKAKDDLEMSAVITIMQPILRFLQLLCENHN
RDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLT
EYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIME
SRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGENGEDGAASPRNVGHNIYILAH
QLARHNKELQTMLKPGGQVDGDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTK
ESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISF
NLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTI
LRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLI
CAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYL
FFKDDFILEVDRLPNETAVPETGESLANDFLYSDVCRVETGENCTSPAPKEELLPAEETE
QDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIV
LNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHY
LCFIVLVKVKDSTEYTGPESYVAEMIRERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEK
LESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA
NT seq 8250 nt NT seq  +upstreamnt  +downstreamnt
atgtctgacaaaatgtcgagtttcctacatattggagacatttgttctctgtatgcggag
ggatctacgaatggatttatcagcaccttaggcttggttgatgaccgttgtgttgtacag
ccagaagccggggaccttaacaatccacccaagaaattcagagactgcctctttaagcta
tgtcctatgaatcgatactccgcacagaaacagttctggaaagctgctaagcccggggcc
aacagcactacagatgcagtgctgctcaacaaattgcatcatgctgcagacttggaaaag
aagcagaatgagacagaaaacaggaaattgttggggaccgtcatccaatatggcaacgtg
atccagctcctgcatttgaaaagcaataaatacctgactgtgaataagaggctcccagcc
ttgctagagaagaacgccatgagggtgacgttggacgaggctggaaatgaagggtcctgg
ttttacattcaaccattctacaagcttcgctccatcggagacagtgtggtcataggcgac
aaggtagttttgaatcctgtcaatgctggccagcctctacatgccagcagtcatcagctg
gtggataacccaggctgcaatgaggtcaactccgtcaactgtaatacaagctggaagata
gtgcttttcatgaaatggagtgataacaaagacgatattctcaaaggaggtgatgtggtg
aggctcttccatgccgagcaagagaagtttctcacctgcgatgagcaccggaagaagcag
catgtgttcctgaggaccaccggcaggcagtcagccacatcggccaccagttccaaagcc
ctgtgggaagtggaggtagtccagcacgacccatgtcggggtggagctgggtactggaat
agcctcttccggttcaagcacctggctacagggcattacttggctgcagaggtagaccct
gactttgaggaagaatgcctggagtttcagccctcagtggaccctgatcaggatgcatct
cggagtaggttgagaaacgcgcaagaaaaaatggtatactctctggtctccgtgcctgaa
ggcaacgacatctcctccatctttgagctagaccccacgactctgcgtggaggtgacagc
cttgtcccaaggaactcctatgtccgtctcagacacctgtgcaccaacacctgggtacac
agcacaaacatccccatcgacaaggaagaggagaagcctgtgatgctgaaaattggtacc
tctcccctgaaggaggacaaggaagcatttgccatagttcctgtttcccctgctgaggtt
cgggacctggactttgccaatgatgccagcaaggtgctgggctccatcgctgggaagttg
gaaaagggcacaatcacccagaatgagagaaggtctgtcacgaagcttttggaagacttg
gtttactttgtcacgggtggaactaactctggccaagacgtgcttgaagttgtcttctct
aagcccaatcgagagcggcagaagctgatgagggaacagaatattctcaagcagatcttc
aagctgttgcaggcccccttcacggactgcggggatggcccgatgcttcggctggaggag
ctgggggatcagcgccatgctcctttcagacatatttgccgactctgctacagggtcctg
cgacactcacagcaagactacaggaagaaccaggagtacatagccaagcagtttggcttc
atgcagaagcagattggctatgacgtgctggccgaagacaccatcactgccctgctccac
aacaaccggaaactcctggagaagcacatcaccgcggcagagattgacacgtttgtcagc
ctggtgcgaaagaacagggagcccaggttcttggattacctctctgacctctgcgtatcc
atgaacaagtcaatccctgtgacacaggagctcatctgtaaagctgtgctcaatcccacc
aatgctgacatcctgattgagaccaagctggttctttctcgttttgagtttgaaggcgtt
tccactggagagaatgctctggaagccggggaggatgaggaagaggtgtggctgttctgg
agggacagcaacaaagagatccgtagtaagagtgtccgggaattggcgcaagatgctaaa
gagggacagaaggaagacagggacatcctcagctactacagatatcagctgaacctcttt
gcaaggatgtgtctggaccgccagtacctggccatcaatgaaatctccgggcagctggat
gttgatctcattctccgctgcatgtctgacgagaacctcccctacgacctcagggcatcc
ttttgccgcctcatgcttcacatgcatgtggaccgagatccccaagagcaggtgacacct
gtgaaatatgcccgactgtggtcagaaattccctctgagatcgccattgatgactatgac
agcagtggaacatccaaagatgaaattaaggagaggtttgcacagacgatggagtttgtg
gaggagtacctaagagatgtggtttgtcaaagattccccttctctgataaggagaaaaat
aagctcacgtttgaggttgtgaacttagccaggaatctcatatactttggtttctacaac
ttttctgaccttctccgattaaccaagatcctcttggcaatcttagactgtgtccatgtg
accactatcttccccattagcaagatgacaaaaggagaagagaataaaggcagtaacgtg
atgaggtctatccatggcgttggggagctgatgacccaggtggtgctgcggggaggaggc
ttcttgcccatgactcccatggctgcggcccctgaaggaaatgtgaagcaggcagagcca
gagaaagaggacatcatggtcatggacaccaagttgaagatcattgaaatactccagttt
attttgaatgtgagattggattataggatctcctgcctcctgtgtatatttaagcgagag
tttgatgaaagcaattcccagtcatcagaaacatcctccggaaacagcagccaggaaggg
ccaagtaatgtgccaggtgctcttgactttgaacacattgaagaacaagcggaaggcatc
tttggaggaagtgaggagaacacacctttggacctggatgaccatggtggcagaaccttc
ctcagggtcctgctccacttgacaatgcatgactacccacccctggtgtctggggccctg
cagctcctctttcggcacttcagccagaggcaggaggtccttcaggccttcaaacaggtt
caactgctggttactagccaagatgtggacaactacaaacagatcaagcaagacttggac
caactaaggtccattgtggagaagtctgagctctgggtgtacaaaggccaaggtcccgat
gagcctatggacggagcctccggtgaaaatgagcataagaaaaccgaggaggggacgagc
aagccactgaagcacgagagcaccagcagctacaactaccgagtggtgaaagagattttg
attcgacttagcaagctctgcgtgcaggagagcgcgtcggtgaggaagagccggaagcag
cagcaacgactgctgaggaacatgggcgcacacgctgtggtgctggagctgctgcagatc
ccctacgagaaggccgaagacacaaagatgcaagagatcatgcggctggctcatgaattt
ttgcagaatttctgtgcaggcaaccagcagaatcaagctttgctgcataaacacataaac
ctgtttctcaacccagggatcctggaggcagtgacgatgcagcacatcttcatgaacaac
ttccagctgtgcagtgagatcaacgagagagtggtccagcactttgttcactgcatagag
acccacggtcgaaacgtccagtatatcaagtttctccagacgattgtcaaggcagaaggg
aaattcattaaaaagtgccaagacatggtcatggctgagcttgtcaactctggagaggac
gtcctcgtgttctacaatgacagagcctctttccagactctgatccagatgatgcggtcc
gagcgtgaccggatggatgagaacagccctctcatgtaccacatccatctggtggagctc
ttggccgtgtgcacagagggcaagaatgtgtacacggagatcaagtgcaactccttgctc
ccgctcgatgacatcgttcgtgtggtcactcatgaagactgcatccccgaggttaagatc
gcttacattaacttcctgaatcactgctatgtggatacggaggtggagatgaaggagatt
tacacaagcaaccacatgtggaagttgtttgagaatttcctcgtggacatctgcagggcc
tgtaacaacacaagcgacaggaagcacgcagactccattctggagaagtacgtcactgaa
atcgtgatgagcatcgtcaccaccttcttcagctctcccttctcagaccagagcaccact
ctgcagacccgccagcctgtctttgtgcaactcctgcaaggcgtgttccgagtttaccac
tgcaactggctgatgccgagccaaaaagcctcggtggagagctgcatccgggtgctctct
gacgtagccaagagccgggccatagccattcctgttgacctggacagccaagtcaacaac
ctcttcctgaagtcccacaacattgtgcagaaaacagccctgaactggcggttatcagcc
cgaaacgccgctcgcagagactctgtactggcagcatccagagactaccgaaatatcatt
gagaggttacaggacatcgtgtctgccctagaggaccggctcaggcccctggtgcaggct
gagctgtctgtgctcgtggatgttctacacagaccagaactgctcttccccgagaacacg
gatgccaggaggaaatgtgagagtggaggtttcatctgcaagctaataaaacataccaag
caactgctggaggagaatgaagagaaactatgcattaaagtcttacagaccctcagggaa
atgatgaccaaagacagaggctatggagagaagcaaatttccattgatgaatcggaaaat
gccgagctgccacaggcaccggaagctgagaactccacagagcaggagcttgaaccaagt
ccacccctgaggcaactggaagaccataaaaggggtgaggcactccgacaaattttggtc
aaccgttactatggaaacatcagaccttcaggaagaagagagagccttaccagctttggc
aatggcccactatcaccaggaggacccagcaagcctggtggaggagggggaggtcctgga
tctagttccacaagcaggggtgagatgagcctggctgaggttcagtgtcacctcgacaag
gagggggcctccaacctggtcatcgatctcataatgaatgcatccagtgaccgagtattc
catgaaagcattctgctggccatcgcacttctggaaggaggcaacaccaccatccagcac
tcgtttttctgccggctgacagaagataagaaatcagagaagttcttcaaggttttttac
gatcgaatgaaggtggcccagcaggaaatcaaggcgacagtgacagtgaacaccagcgac
ttgggaaacaaaaagaaagatgatgaagtggacagggatgccccgtctcggaagaaagcc
aaagagcccacaacacagataacagaagaggtccgggatcagctcctggaagcatctgct
gccaccaggaaagcctttaccaccttccggagggaggccgaccctgatgaccattaccag
tctggggagggcacccaggctacaaccgacaaagccaaggatgacctagagatgagcgct
gtcatcaccatcatgcagcctatcctgcgcttcctgcagctgctgtgtgaaaaccacaac
cgagatctgcagaatttccttcgttgccaaaataataagaccaactacaatttggtgtgt
gagacactgcagtttctggactgtatttgtgggagcacaaccggaggccttggtcttctt
ggactgtacataaatgaaaagaatgtagcacttatcaaccaaaccctggagagtctgacg
gagtactgtcaagggccttgccatgagaaccagaactgcatcgccacccacgagtccaat
ggcatcgatatcatcacagccctcatcctcaatgatatcaaccctctgggaaagaagcgg
atggacctggtgttagaactgaagaacaatgcttcgaagctgctactggccatcatggaa
agcagacacgatagtgaaaatgcagagaggatcctgtacaacatgaggcccaaggagctg
gtggaagtgatcaagaaggcctacatgcaaggtgaagtggaatttgaggatggggagaac
ggtgaggatggagctgcctcacccaggaacgtgggccacaacatctacatcctcgctcac
cagttggctcggcataacaaagaacttcaaaccatgctgaaacctggaggccaggtggat
ggggatgaagctctggagttctacgcgaagcacacagcacaaattgagattgtcagactg
gaccggacaatggaacagatcgtcttccctgtgcccagcatctgtgaattcctgactaag
gaatcgaaacttcgaatatattacaccacagagcgggatgagcaaggtagcaagatcaat
gacttcttcctgcgctccgaggacctctttaacgagatgaactggcagaagaaacttcga
gcccagcctgtcttgtactggtgtgcccgaaacatgtctttctggagcagcatctccttc
aacctggccgtcctgatgaacctgctggtggcgtttttctatccatttaaaggagtaagg
ggaggaacactagagccacactggtcaggccttctgtggacagccatgctcatctctctg
gccattgtcattgctctgcccaagccccacggcatccgggccttaattgcttctacaatc
ctacgactgatattttcagttgggttgcagcccacactgtttctgctgggagctttcaat
gtctgcaataaaatcatcttcctgatgagctttgtgggcaactgtgggaccttcaccaga
ggctaccgggccatggttctggatgtggagttcctctatcatttgctgtatctactcatc
tgtgccatgggcctcttcgtacatgagttcttctatagcttgctgctttttgatttagtg
tacagagaggagactttgcttaatgtcattaaaagtgtcacccgcaatggacggtccatc
atcttgacagcggtcctggctctgatcctggtttacctgttctcaattgtgggctatctg
ttcttcaaggatgactttatcttggaagtagataggttgcccaatgaaacagctgttcca
gaaactggcgagagtttggccaacgatttcctgtactctgatgtgtgcagggtagagacg
ggggagaactgcacctctcctgcacccaaagaagagctgctccctgccgaagaaacggaa
caggataaggaacacacgtgtgagaccctgctcatgtgcatcgtcactgttctgagtcac
gggctgcggagtgggggaggggtaggagacgtgctcaggaagccatccaaagaggagcct
ctgtttgctgcaagggtgatctacgacctcctcttcttcttcatggtcatcatcatcgtc
ctgaacctgattttcggggtcatcattgacacctttgctgacctgaggagtgagaagcaa
aagaaggaggagatcttaaaaaccacgtgcttcatctgcggcttggaaagggacaagttt
gacaataagactgtcacctttgaagagcacatcaaggaagagcacaacatgtggcactat
ctgtgcttcatcgtgctggtgaaagtgaaggactccacagagtacaccgggcctgagagt
tacgtggcagagatgatcagggaaagaaaccttgattggttccccagaatgagagccatg
tccctggtcagcagcgattctgaaggggaacagaacgagctgaggaacctgcaggagaag
ctggagtctaccatgaagctggtcaccaatctttctggccagctgtcagaactaaaggac
cagatgacagaacagaggaagcagaaacaaagaatcggccttctaggacatcctcctcac
atgaatgtcaacccacagcagccggcctag

KEGG   Mus musculus (mouse): 16439Help
Entry
16439             CDS       T01002                                 

Gene name
Itpr2, AI649341, InsP3R-2, InsP3R-5, Ip3r2, Itpr5, insP3R2
Definition
(RefSeq) inositol 1,4,5-triphosphate receptor 2
  KO
K04959  inositol 1,4,5-triphosphate receptor type 2
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04070  Phosphatidylinositol signaling system
mmu04114  Oocyte meiosis
mmu04210  Apoptosis
mmu04218  Cellular senescence
mmu04270  Vascular smooth muscle contraction
mmu04371  Apelin signaling pathway
mmu04540  Gap junction
mmu04611  Platelet activation
mmu04621  NOD-like receptor signaling pathway
mmu04625  C-type lectin receptor signaling pathway
mmu04720  Long-term potentiation
mmu04723  Retrograde endocannabinoid signaling
mmu04724  Glutamatergic synapse
mmu04725  Cholinergic synapse
mmu04726  Serotonergic synapse
mmu04728  Dopaminergic synapse
mmu04730  Long-term depression
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04912  GnRH signaling pathway
mmu04915  Estrogen signaling pathway
mmu04918  Thyroid hormone synthesis
mmu04921  Oxytocin signaling pathway
mmu04922  Glucagon signaling pathway
mmu04924  Renin secretion
mmu04925  Aldosterone synthesis and secretion
mmu04927  Cortisol synthesis and secretion
mmu04928  Parathyroid hormone synthesis, secretion and action
mmu04934  Cushing syndrome
mmu04970  Salivary secretion
mmu04971  Gastric acid secretion
mmu04972  Pancreatic secretion
mmu05010  Alzheimer disease
mmu05163  Human cytomegalovirus infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05170  Human immunodeficiency virus 1 infection
mmu05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    16439 (Itpr2)
   04020 Calcium signaling pathway
    16439 (Itpr2)
   04070 Phosphatidylinositol signaling system
    16439 (Itpr2)
   04022 cGMP-PKG signaling pathway
    16439 (Itpr2)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    16439 (Itpr2)
   04210 Apoptosis
    16439 (Itpr2)
   04218 Cellular senescence
    16439 (Itpr2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    16439 (Itpr2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    16439 (Itpr2)
   04621 NOD-like receptor signaling pathway
    16439 (Itpr2)
   04625 C-type lectin receptor signaling pathway
    16439 (Itpr2)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    16439 (Itpr2)
   04912 GnRH signaling pathway
    16439 (Itpr2)
   04915 Estrogen signaling pathway
    16439 (Itpr2)
   04921 Oxytocin signaling pathway
    16439 (Itpr2)
   04918 Thyroid hormone synthesis
    16439 (Itpr2)
   04928 Parathyroid hormone synthesis, secretion and action
    16439 (Itpr2)
   04924 Renin secretion
    16439 (Itpr2)
   04925 Aldosterone synthesis and secretion
    16439 (Itpr2)
   04927 Cortisol synthesis and secretion
    16439 (Itpr2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    16439 (Itpr2)
  09154 Digestive system
   04970 Salivary secretion
    16439 (Itpr2)
   04971 Gastric acid secretion
    16439 (Itpr2)
   04972 Pancreatic secretion
    16439 (Itpr2)
  09156 Nervous system
   04724 Glutamatergic synapse
    16439 (Itpr2)
   04725 Cholinergic synapse
    16439 (Itpr2)
   04728 Dopaminergic synapse
    16439 (Itpr2)
   04726 Serotonergic synapse
    16439 (Itpr2)
   04720 Long-term potentiation
    16439 (Itpr2)
   04730 Long-term depression
    16439 (Itpr2)
   04723 Retrograde endocannabinoid signaling
    16439 (Itpr2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    16439 (Itpr2)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    16439 (Itpr2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    16439 (Itpr2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    16439 (Itpr2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    16439 (Itpr2)
   05163 Human cytomegalovirus infection
    16439 (Itpr2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    16439 (Itpr2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:mmu04040]
    16439 (Itpr2)
Ion channels [BR:mmu04040]
 Ligand-gated channels
  IP3 receptor
   16439 (Itpr2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ins145_P3_rec RYDR_ITPR MIR RIH_assoc Ion_trans DUF2207 MREG
Motif
Other DBs
NCBI-GeneID: 16439
NCBI-ProteinID: NP_064307
MGI: 99418
Ensembl: ENSMUSG00000030287
Vega: OTTMUSG00000025625
UniProt: Q9Z329 Q8CED6
LinkDB All DBs
Position
6 G3; 6 77.7 cM
AA seq 2701 aa AA seqDB search
MSDKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKV
CPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENRKLLGEIVKYSNV
IQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD
KVVLMPVNAGQPLHASNVELLDNPGCKEVNAVNCNTSWKITLFMKFSSYREDVLKGGDVV
RLFHAEQEKFLTCDDYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWN
SLFRFKHLATGNYLAAELNPDYRDAQNEGKNVKDGEIPTPKKKRQAGEKIMYTLVSVPHG
NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTTIPIDTEEERPVMLKIGTC
QTKEDKEAFAIVCVPLSEVRDLDFANDANKVLATTVKKLENGSITQNERRFVTKLLEDLI
FFVADVTNNGQDVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED
LGDQRYAPYKYVLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLH
NNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNSTAIPVTQELICKFMLSPG
NADILIQTKLVSMQVENPMESSILPDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAREGT
KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCR
LMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEE
YLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM
SSYFERLSKFQDGSNNVMRTIHGVGEMMTQMVLSRGSIFPVSVPDAQPIVHPSKQASPGE
QEDVTVMDTKLKVIEILQFILSVRLDYRISYMLSIYKKEFGDNNDNGDPSASGTPDTLLP
SALVPDIDEIAAQAETMFAGRKEKTPVQLDDEGGRTFLRVLIHLIMHDYAPLLSGALQLL
FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSGSYENGD
VGEGQAKGGEEANEESNLLSPVQDGAKTPQIDSNKGNNYRIVKEILIRLSKLCVQNKKCR
NQHQRLLKNMGAHSVVLDLLQIPYEKTDEKMNEVMDLAHTFLQNFCRGNPQNQVLLHKHL
NLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD
GKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLNMMCSERARGDESGPLAYHITLVE
LLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKE
IYTSNHIWKLFENFLVDMARVCNTTTDRKHADTFLERCVTESVMNIVSGFFNSPFSDNST
SLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRALAEVAKNRGIAIPVDLDSQVN
TLFMKNHSSTVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEQQFSPM
MQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLRE
MLEKKDSFMEEGSTLRRILLNRYFKGDHSISVNGPLSGAYAKTAQVGGSFSGQDSDKKGI
SMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGILLGIALLEGGNTQTQYSFYQQLHEQ
KKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGSKKREEDSDVMALGPRMRVRDSSLHLR
EGMKGQLTEASSATSKAYCVYRREMDPEIDTMCPGQEAGSAEEKSAEEVTMSPAITIMRP
ILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINER
NVALVNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQL
KNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDEEGGDDGVS
PKDVGHNIYILAHQLARHNKLLQQMLKPGSDPEEGDEALKYYANHTAQIEIVRHDRTMEQ
IVFPVPNICEFLTRESKYRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALF
WFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPMFSVLLWVAVAICTSMLFF
FSKPVGIRPFLVSVMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAV
ILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAV
LALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGNHGVPTMTLSSMMETCQKENCSPT
IPSSNTAGEEGEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVY
DLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE
EHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMITEKNLDWFPRMRAMSLVSNEGD
SEQNEIRNLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPP
H
NT seq 8106 nt NT seq  +upstreamnt  +downstreamnt
atgtctgacaaaatgtccagcttcctctacattggggacatcgtgtccctgtacgcggag
ggctcggtcaatggcttcatcagcaccctggggttggtggatgaccgttgtgtggtgcac
ccagaggcgggagaccttgccaacccacccaagaagttcagagactgcctgttcaaggtg
tgccctatgaatcgatactctgcccagaagcaatactggaaagccaagcaggcgaaacag
gggaaccatacagaggctgccctgctgaagaagctccagcatgctgcagagctggaacaa
aaacagaatgagtcggagaacaggaaacttttgggagaaatcgtgaaatacagcaacgtt
atccaactgctgcacataaaaagcaacaagtacctgacggtgaacaagaggttacctgcc
ttgctggagaagaatgccatgcgagtgtcactggatgctgcagggaacgaaggctcctgg
ttctacatccatccgttctggaagctgagaagcgagggtgataatatcgtcgtaggagat
aaagtcgttctgatgcctgtaaatgctgggcagcccctgcatgccagcaacgtggagctc
ttggacaacccaggctgcaaagaggtgaatgctgttaattgtaacactagctggaaaatc
actttattcatgaaattcagttcctatcgagaggatgtattaaaggggggtgatgttgtg
agactctttcatgcggaacaagagaaatttctgacctgtgatgactatgagaaaaaacag
cacattttccttcggacgaccttgcgtcaatcagcaacttcggccactagttctaaagca
ctctgggaaatagaggtggttcaccacgatccatgccgcggaggtgcgggacagtggaac
agcctgttcaggtttaagcatcttgccactgggaactacttagctgcagagcttaatcct
gactatcgagatgctcaaaatgaaggaaaaaatgtgaaagacggggagattccaacacca
aagaaaaaacgccaggcaggggagaagatcatgtacaccctggtttcagtcccacacgga
aatgacatcgcgtccctttttgaacttgatgccacaactctgcagagagccgactgcctg
gttccgaggaactcctacgtgcggttaaggcacttgtgcaccaacacctgggtaacaagc
accaccatccccatagacacagaggaagagaggcctgtcatgttgaaaattgggacctgc
cagaccaaggaagacaaagaagcctttgccattgtgtgcgtcccgctgtctgaggtccgt
gacttggactttgccaacgatgccaacaaagtgctggccaccacggtgaagaagctggag
aatggcagcatcacacagaacgagaggaggtttgtgactaagttgttggaagacctcatt
ttctttgtggctgatgtgaccaacaatgggcaggacgttctggatgtggtcatcaccaag
ccaaaccgggaacggcagaaactaatgagggaacagaatatactggcacaggtgtttggg
atccttaaagcacctttcaaggagaaggctggagaaggttcgatgctgaggctggaggac
ctgggcgaccagcgctacgccccgtacaagtatgtgctgcgtctctgctaccgtgtgctg
cggcattcgcagcaggactacaggaagaaccaggagtacattgctaagaacttctgcgtt
atgcagtcccagatcggctatgatatcttggcagaagatacgattacagccttgttacac
aacaaccgcaaactactggagaaacacatcacagccaaagaaattgagactttcgtcagc
ctgctcaggaggaaccgggagccgaggtttctggactatttgtctgacctctgtgtgtcc
aatagcacggccatccccgtcactcaggaactcatctgcaaattcatgctgagccctggc
aatgcggacatcctcattcagacaaagctggtgtccatgcaagtggagaaccccatggag
agctccatccttcctgatgacattgacgatgaggaggtctggctttactggattgacagc
aacaaggagcctcacggcaaggccatcaggcaccttgcccaggaagccagggaaggcacc
aaagctgacctggaagttctgacctattacaggtaccagctaaacctctttgcaaggatg
tgcttggaccgccagtatctggccatcaaccagatttcaacacagttgtccgtagacctg
atcctgcggtgtgtgtctgacgagagtctgccctttgacctcagagcatctttctgccga
ctcatgctccacatgcacgttgaccgcgacccccaggagtctgtagtgcctgttcgctat
gcccgcctctggaccgaaatccccacaaagatcacgattcatgagtatgactccattaca
gactcttccagaaatgacatgaagaggaagtttgccctgacgatggaatttgtcgaagaa
tatttgaaagaagttgtaaatcaaccatttccttttggagacaaagagaaaaataaactg
acatttgaggtggttcacctagcccggaacctcatctatttcggattctacagcttcagc
gagttactgcggctgacgagaactctgctggcgatcctagacatcgtccaggcccccatg
tcctcatatttcgaaagattaagcaagttccaagatggaagcaacaatgtcatgaggacc
atccacggagtgggagagatgatgacacagatggtgctcagcagaggctccatcttccca
gtgagtgtgcccgacgcacagcccatcgtccaccccagcaagcaggcgagccccggcgag
caggaggatgtgacagtgatggacaccaagctgaaggttatcgagattttacagttcatc
ctgagcgtcaggctggactaccggatctcttacatgctgtccatatacaagaaggaattt
ggagacaacaacgacaatggtgacccctctgccagcggcaccccagacacactgctacca
tcagctcttgtccctgacatcgacgagattgcggctcaggcagaaacaatgttcgctgga
agaaaagaaaaaactccagttcagcttgatgatgaaggaggcaggacgttcttacgcgtc
ctcatccacctgatcatgcacgactatgctccgctgctgtccggagccctgcagctgctc
ttcaagcatttcagccagagagcagaagtgcttcaggcctttaaacaggtgcagttacta
gtgtcgaaccaagatgttgataactacaagcaaatcaaggcagacctcgaccaacttcgg
ctgacggtggagaaatctgagctgtgggtagaaaagagcggcagctatgagaatggagat
gtgggtgagggccaggccaaaggaggcgaagaggcaaatgaggaatccaacctcttgagc
ccggtgcaggatggcgcgaagacacctcagatcgacagcaacaagggcaacaactaccgg
atcgtcaaggagatcttgattaggctgagtaagctctgtgtgcagaacaagaaatgccgt
aatcaacaccagcggctgctgaaaaacatgggggctcactccgtggtgctggaccttctg
cagatcccctatgagaagaccgacgagaagatgaacgaggtgatggacttagcccacacc
ttcctgcagaacttctgccgtgggaatccgcagaaccaagttctccttcacaagcatctc
aatctgttcctaactcctggcctcctggaggcagaaaccatgcggcacatcttcatgaac
aattatcacctgtgcaacgagatcagcgagagggtggtccagcacttcgtgcactgcatt
gagacacatggccgccatgtggagtacctgaggttcctgcagacgatcgtgaaagcagat
ggcaaatacgtgaagaaatgccaggacatggtgatgacggagttgatcaatgggggcgag
gatgtgttgatattctacaatgacagagcttcatttcccatcctcctcaacatgatgtgc
tctgagagagcccgtggggacgagagcggccccctcgcctaccacatcacccttgtggag
ttgctggcagcgtgcaccgaaggcaaaaatgtctacacagaaatcaagtgcaattctctc
ttgcctctggacgacatagtgagagtggtgacccacgatgactgcattcctgaggtcaaa
atcgcgtacgtgaactttgtcaaccattgctacgttgacactgaagtggagatgaaggag
atctacacaagtaaccacatttggaagttatttgagaatttcttggtggatatggcgagg
gtctgtaacaccaccacagacaggaaacacgcagacacctttctggagaggtgtgtgaca
gagtcagtcatgaacattgtgagcggcttcttcaactcgccattttccgacaacagtacc
agcctccagacccaccagccagtctttatccagctgctgcagtctgccttcagaatttac
aactgtacctggcccaacccagcccagaaagcctccgtagaatcctgtatcagagccctg
gctgaagtggccaaaaaccgtgggattgcgatcccagtcgatttggacagccaggtcaac
acgctcttcatgaagaaccactcaagtacggtgcagagggcagccatgggctggagactc
tcagctcgctctggacctcgcttcaaggaagctcttggaggaccagcctgggattacaga
aatattattgaaaagttacaggatgtcgtggcctccctggaacagcagttcagccccatg
atgcaggccgagttctctgtgcttgtggatgtgctgtacagcccggagctactgttccca
gagggaagcgacgccaggatccgatgtggtgccttcatgtccaagctgattaatcacaca
aagaaactgatggagaaagaagaaaagctgtgcattaaaatcctccagactttacgggag
atgctggagaagaaagacagcttcatggaagagggtagcacattacggcgaatcctcctg
aatcggtacttcaagggtgatcatagcattagtgtgaacggacctctgtcaggagcctat
gccaagacagcacaagtgggaggaagcttctctggacaggattcagataagaagggcatt
tcaatgtccgatatccagtgtttgctggacaaagaaggagcatccgaacttgtcatcgat
gtcattgtgaacaccaaaaacgacaggatcttttccgaaggaattttgcttggcattgcc
ttgctggaaggaggaaacacacagacccagtattctttctaccagcagttgcatgaacaa
aaaaagtcagagaaatttttcaaagtcctttatgatcggatgaaggctgctcagaaagag
atcagatccacggtgaccgtcaacaccatagacttagggagcaagaagagagaagaggac
agtgacgtcatggccctgggccctcggatgagagtgagagactcatcactacatttgaga
gaaggaatgaaagggcagttaacagaagcgtcttcagccacatccaaagcatactgtgtg
tacagaagagagatggacccggaaatagacacaatgtgcccgggacaggaagcaggaagt
gcggaggaaaagtctgcggaggaagttaccatgagcccggccatcaccatcatgcgtccc
atcctcaggttcctgcagttactgtgtgagaatcataaccgggagcttcagaacttcttg
aggaaccagaacaacaaaacaaactacaaccttgtctgtgaaacgcttcagttcctggac
tgtatctgcggaagtaccacagggggtctaggcctgctggggctctacatcaatgagagg
aatgtagctctggtcaaccagactctggagagcttgaccgagtactgccaaggcccgtgc
cacgagaaccagacctgtatcgccactcacgaatccaatgggattgatatcatcatcgcc
ttgattctgaatgacatcaaccccctgggcaagtacagaatggacttggtgttgcagctg
aagaacaacgcctccaagcttctgctggccattatggagagcagacatgacagtgagaat
gcagagagaattcttttcaacatgagacccagggaactggtggatgtcatgaagaatgcc
tataaccaaggcctggaatgtgaccatggggacgaggagggaggggatgatggtgtttct
ccaaaagacgttggacacaacatctacattctggcccatcagttggcccgccacaacaaa
ctgctgcagcagatgctcaagccgggatctgacccagaggaaggggatgaagctttgaag
tattacgccaaccacaccgcgcagatcgagattgtgcggcatgaccggactatggagcag
attgttttcccggtccccaacatctgtgaattcctcactcgggaatccaagtaccgagtg
ttcaacacaacggagagggatgagcaaggaagcaaggtgaacgacttcttccagcaaacg
gaagatctctacaacgagatgaaatggcaaaagaagatcagaaacaaccccgccctgttc
tggttctccaggcacatctcactctgggggagcatctccttcaacctggctgtgttcatc
aacctggctgtggctctcttctacccattcggggatgacggtgatgaaggcacactctcc
ccgatgttctcagtcctcctttgggtagcagtggcgatctgcacatctatgctgttcttc
ttctccaagcccgtgggcatccggccattcctcgtgtctgtcatgctcagatcgatatac
accatcggtctggggccaacgctaatactacttggtgctgccaatctatgtaataaaatc
gtgttcctggtgagttttgtgggaaaccgaggcacattcaccagaggctaccgagcagtc
attctggacatggcctttctttaccacgtggcctatgtcctggtttgcatgcttggcctc
tttgtccacgagttcttctacagcttcctgctttttgatttggtatatagagaagagacc
ctgctgaatgtcatcaaaagcgtcacacggaacggccgctccatcatcctgaccgcggtc
ttggctcttatcttggtctacctgttctccatcatcggcttccttttcttaaaggacgac
ttcaccatggaggtggacagactgaaaaacagaactccagtcacaggtaatcacggggtt
cccactatgaccttatcttccatgatggaaacctgccagaaggaaaactgctcacccacg
atcccctcttccaacacagccggcgaggaaggtgaggatggcatagaaaggacatgtgat
accctgctcatgtgcattgtcaccgtgctgaaccagggcctcaggaatggcggcggagtt
ggggatgtgctgagacgaccctcgaaagatgagcccttgtttgctgcccgggtagtctac
gacctcctgttcttcttcatcgtcatcatcatcgttctcaacctgatctttggagtgatc
attgacacgtttgctgacctcagaagtgagaagcagaagaaagaagaaatcctcaagaca
acctgcttcatctgtggcctggagagagacaagtttgataacaagacagtgtcctttgag
gagcacatcaagtcagagcacaacatgtggcattacctgtacttcatcgtcctggtgaag
gtgaaggacccgacagaatacacagggcctgagagctacgtggctcagatgatcacggag
aagaatttggactggtttcctcggatgcgagccatgtcacttgtcagcaacgaaggtgac
agtgagcaaaatgagatccggaacctgcaggagaagctggagtctacgatgagtctggtg
aagcagctgtcagggcagctggcagagctgaaggagcagatgacagaacaaaggaaaaac
aagcaaaggctgggctttcttggatcaaacacaccccatgtgaaccatcacatgccaccg
cactga

KEGG   Mus musculus (mouse): 16440Help
Entry
16440             CDS       T01002                                 

Gene name
Itpr3, IP3R_3, Ip3r3, Itpr-3, tf
Definition
(RefSeq) inositol 1,4,5-triphosphate receptor 3
  KO
K04960  inositol 1,4,5-triphosphate receptor type 3
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04070  Phosphatidylinositol signaling system
mmu04114  Oocyte meiosis
mmu04210  Apoptosis
mmu04218  Cellular senescence
mmu04270  Vascular smooth muscle contraction
mmu04371  Apelin signaling pathway
mmu04540  Gap junction
mmu04611  Platelet activation
mmu04621  NOD-like receptor signaling pathway
mmu04625  C-type lectin receptor signaling pathway
mmu04713  Circadian entrainment
mmu04720  Long-term potentiation
mmu04723  Retrograde endocannabinoid signaling
mmu04724  Glutamatergic synapse
mmu04725  Cholinergic synapse
mmu04726  Serotonergic synapse
mmu04728  Dopaminergic synapse
mmu04730  Long-term depression
mmu04742  Taste transduction
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04911  Insulin secretion
mmu04912  GnRH signaling pathway
mmu04915  Estrogen signaling pathway
mmu04918  Thyroid hormone synthesis
mmu04921  Oxytocin signaling pathway
mmu04922  Glucagon signaling pathway
mmu04924  Renin secretion
mmu04925  Aldosterone synthesis and secretion
mmu04927  Cortisol synthesis and secretion
mmu04928  Parathyroid hormone synthesis, secretion and action
mmu04934  Cushing syndrome
mmu04970  Salivary secretion
mmu04971  Gastric acid secretion
mmu04972  Pancreatic secretion
mmu05010  Alzheimer disease
mmu05163  Human cytomegalovirus infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05170  Human immunodeficiency virus 1 infection
mmu05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    16440 (Itpr3)
   04020 Calcium signaling pathway
    16440 (Itpr3)
   04070 Phosphatidylinositol signaling system
    16440 (Itpr3)
   04022 cGMP-PKG signaling pathway
    16440 (Itpr3)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    16440 (Itpr3)
   04210 Apoptosis
    16440 (Itpr3)
   04218 Cellular senescence
    16440 (Itpr3)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    16440 (Itpr3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    16440 (Itpr3)
   04621 NOD-like receptor signaling pathway
    16440 (Itpr3)
   04625 C-type lectin receptor signaling pathway
    16440 (Itpr3)
  09152 Endocrine system
   04911 Insulin secretion
    16440 (Itpr3)
   04922 Glucagon signaling pathway
    16440 (Itpr3)
   04912 GnRH signaling pathway
    16440 (Itpr3)
   04915 Estrogen signaling pathway
    16440 (Itpr3)
   04921 Oxytocin signaling pathway
    16440 (Itpr3)
   04918 Thyroid hormone synthesis
    16440 (Itpr3)
   04928 Parathyroid hormone synthesis, secretion and action
    16440 (Itpr3)
   04924 Renin secretion
    16440 (Itpr3)
   04925 Aldosterone synthesis and secretion
    16440 (Itpr3)
   04927 Cortisol synthesis and secretion
    16440 (Itpr3)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    16440 (Itpr3)
  09154 Digestive system
   04970 Salivary secretion
    16440 (Itpr3)
   04971 Gastric acid secretion
    16440 (Itpr3)
   04972 Pancreatic secretion
    16440 (Itpr3)
  09156 Nervous system
   04724 Glutamatergic synapse
    16440 (Itpr3)
   04725 Cholinergic synapse
    16440 (Itpr3)
   04728 Dopaminergic synapse
    16440 (Itpr3)
   04726 Serotonergic synapse
    16440 (Itpr3)
   04720 Long-term potentiation
    16440 (Itpr3)
   04730 Long-term depression
    16440 (Itpr3)
   04723 Retrograde endocannabinoid signaling
    16440 (Itpr3)
  09157 Sensory system
   04742 Taste transduction
    16440 (Itpr3)
   04750 Inflammatory mediator regulation of TRP channels
    16440 (Itpr3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    16440 (Itpr3)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    16440 (Itpr3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    16440 (Itpr3)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    16440 (Itpr3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    16440 (Itpr3)
   05163 Human cytomegalovirus infection
    16440 (Itpr3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    16440 (Itpr3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:mmu01009]
    16440 (Itpr3)
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:mmu04040]
    16440 (Itpr3)
Protein phosphatases and associated proteins [BR:mmu01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     16440 (Itpr3)
Ion channels [BR:mmu04040]
 Ligand-gated channels
  IP3 receptor
   16440 (Itpr3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ins145_P3_rec RYDR_ITPR MIR RIH_assoc Ion_trans
Motif
Other DBs
NCBI-GeneID: 16440
NCBI-ProteinID: NP_542120
MGI: 96624
Ensembl: ENSMUSG00000042644
Vega: OTTMUSG00000031360
UniProt: P70227
LinkDB All DBs
Structure
PDB: 

Position
17 A3.3; 17 13.68 cM
AA seq 2670 aa AA seqDB search
MNEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVC
PMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGS
VIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVG
DKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDV
VRLFHAEQEKFLTCDEYRGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHW
NGLYRFKHLATGNYLAAEENPSYKGDVSDPKAAGLGAQGRTGRRNAGEKIKYRLVAVPHG
NDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNAPIDVEEERPIRLMLGTC
PTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLV
FFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQIFGILKAPFRDKGGEGPLVRLEE
LSDQKNAPYQYMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLH
NNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNRIAIPVTQELICKCVLDPK
NSDILIQTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDRNNEHHEKSVRQLAQEARAGNA
HDENVLSYYRYQLKLFARMCLDRQYLAIDEISKQLGVELLFLCMADEMLPFDLRASFCHL
MLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFASTMEFVEDY
LNNVVSEAVPFANDEKNILTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCIQAPAA
MLQAYEEPGGKNVRRSIQGVGHMMSTMVLSRKQSVFGASSLPAGVGVPEQLDRSKFEDNE
HTVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSST
ATMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLLHLTMHDYPSLVSGALQLLFK
HFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSVKGEEVE
AGATKDKKERPSDEEGFLQPHGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNM
DAHKVMLDLLQIPYDKSDNKMLEILRYTHQFLQKFCAGNPGNQALLHKHLQLFLTPGLLE
AETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDM
IMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKN
VYTEIKCTSLLPLEDVVTVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTL
FENFTLDMALVCNKREKRLSDPTLEKYVLTVVLDTISAFFSSPFSENSTSLQTHQTIVVQ
LLQSTTRLLECPWLQQQHKGSVEACVRTLAMVAKSRAILLPMDLDAHMSALLSSGGSCSA
AAQRSAANYKTATRTFPRVIPTANQWDYKNIIEKLQDIIMALEERLKPLVQAELSVLVDM
LHWPELLFPEGSEAYQRCESGGFLSKLIRHTKGLMESEEKLCVKVLRTLQQMLLKKSKFG
DRGNQLRKMLLQNYLQNRKSGARGELTDPTGSGLDQDWSAIAATQCRLDKEGATKLVCDL
ITSTKNEKIFQESIGLAIRLLDGGNTEIQKSFYNLMTSDKKSERFFKVLHDRMKRAQQET
KSTVAVNMSDLGSQPREDREPADPATKGRVSSFSMPSSSRYLLGLGLHRGHDMSERAQNN
EMGTSVLIMRPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGG
LGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPL
CKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEEREN
SEVSPREVGHNIYILALQLSRHNKQLQHLLKPVRRIQEEEAEGISSMLSLNNKQLSQMLK
SSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPAICQFLTEETKHRLFTTTEQ
DEQGSKVSDFFDQSSFLHNEMEWQRRLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAF
FYPYVEGASTGVLGSPLISLLFWILICFSIAALFTKRYSVRPLIVALILRSIYYLGIGPT
LNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELFY
SILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDR
LPGNHSRASPLGMPHGAATFMGTCSGDKMDCVSEVSVPEILEEDEEPDSTERACDTLLMC
IVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFA
DLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNKT
DYTGPESYVAQMIKNKNLDWFPRMRAMSLVSGEGEGEQNEIRILQEKLGSTMKLVSHLTS
QLNELKEQMTEQRKRRQRLGFVDVQNCMSR
NT seq 8013 nt NT seq  +upstreamnt  +downstreamnt
atgaatgaaatgtccagctttcttcacatcggggacattgtgtccctgtacgccgagggc
tctgtcaatggcttcatcagcactttggggctggtggatgaccgttgtgtggtggaacct
gcagctggggacctggacaacccccccaagaagttccgagattgcctcttcaaagtgtgc
cccatgaaccgctactctgcacagaaacagtactggaaagccaagcagactaaacaggac
aaagagaagattgctgatgtggtattgctgcagaagctgcagcacgcagcccagatggag
cagaagcaaaatgacacagagaacaagaaggtgcacggggacgtggtgaagtacggcagc
gtgattcagcttctgcatatgaagagcaacaaatacttaactgtgaacaagcggctgcca
gccctgctggagaagaatgccatgcgggtgacgctggatgctacgggcaatgagggctcc
tggctcttcatccagcccttctggaagcttcggagcaatggggataatgtggtcgtgggg
gacaaggtgatcctgaatcctgtcaatgccgggcagcccttacatgccagcaactatgag
cttagtgataatgctggctgcaaagaggtcaactctgtcaactgcaacaccagctggaag
atcaacttattcatgcagttccgggaccacctggaggaggtgctgaaggggggagacgtg
gtgcgactgttccacgcggagcaggagaagttcctgacctgtgatgagtacaggggcaag
ctgcaggtgttcctgcggaccacgctccgccagtccgccacctcggccaccagctccaac
gcactctgggaggtggaggtggtccaccacgacccctgccgcgggggagccggacactgg
aacggtctgtacaggttcaagcacctggccacgggcaactatctggccgctgaggaaaac
cccagctacaagggtgatgtctcagatcctaaggcagctggactgggggcccagggccgc
actggccgcaggaacgcaggcgagaagatcaagtaccgtctggtggctgtgccacatggg
aatgacatcgcgtctctcttcgagctggaccccaccacgctgcagaaaaccgactccttc
gtgccccggaactcctacgtgcggctgcggcacctctgcaccaacacctggatccagagt
accaacgcgcccatcgacgtggaggaggaacggcctatccggctcatgttgggcacatgc
cccaccaaggaggacaaagaggcctttgccattgtgtcggttcctgtgtcggagatccgc
gacctggactttgccaacgacgccagctccatgctggccagcgccgtggagaaactcaac
gaaggcttcatcagccagaacgaccgcaggtttgtcatccagctgttggaggacttggtg
ttttttgtcagcgatgttcccaacaatgggcagaatgtcctggacatcatggtcaccaag
cccaaccgggagcggcagaagctgatgcgggagcagaacatacttaagcagatctttggc
atcctgaaggctccattccgtgacaaggggggtgaaggaccactagtgcggctggaggaa
ctgtctgaccagaagaacgccccctaccagtacatgttccgtctctgctaccgggtgttg
cggcattctcaggaggactaccgcaagaatcaggagcacatagccaagcagtttgggatg
atgcagtcacagattggctatgacatcctggctgaagacaccatcactgccctgctgcac
aacaaccggaagcttctagagaaacacatcaccaagacggaggtggagacctttgtcagt
ctcgtgcgcaagaacagggagcccagattcctggactacctctccgacctgtgcgtgtcc
aaccgtatcgccatccctgtcacccaagagctgatttgcaaatgtgtgctggaccctaag
aacagtgacattcttatccagactgagctgcggccagtgaaggagatggctcagtctcac
gagtacctcagcatcgagtactcagaggaggaggtgtggctcacatggacggacaggaac
aatgagcaccacgagaagagcgtgaggcagctggcccaggaggcgagggctggcaacgca
cacgatgagaacgtgctcagctactacaggtaccagttgaagctgtttgcccgcatgtgc
ctggaccgccagtacttggccattgatgagatctccaagcagctgggtgtcgagctgctt
ttcctgtgcatggctgacgagatgctgccctttgacctccgcgcctcattctgccatctg
atgctacatgtgcacgtggaccgcgaccctcaggagctggtgacccctgtcaagtttgcc
cgcctctggacagagatccccacggccatcaccattaaagactatgattccaatctcaac
gcgtcgagagatgacaaaaaaaacaagtttgccagcaccatggagttcgtagaagattac
ctcaacaacgtggtcagcgaggccgtgccctttgccaacgacgagaagaacatactcacc
tttgaggtggtgagcctggcgcacaatctcatctacttcgggttctacagcttcagcgag
ctgctgaggctcacacgcacgctactgggcatcatagactgcatccaggcaccggcagcc
atgctgcaggcctatgaggagcctggtggcaagaatgtgcggaggtccatccagggggtg
gggcacatgatgtccaccatggtgctgagccgcaagcagtctgtatttggtgcctccagc
ctgcctgctggagtgggtgtccctgagcagctagacagaagcaaatttgaggacaatgag
cacactgtggtgatggagaccaaactgaagatcctggagattctgcagttcatcctgaac
gtacgcttagactaccgcatctcctacctgttgtcggtcttcaagaaggagtttgtggag
gtgtttcccatgcaggacagcggggcggacggcacggcacctgcctttgattcctccact
gccaccatgaatctggaccgcatcggagagcaggcagaggccatgtttggagtagggaag
accagcagcatgctggaggtggacgatgaaggtggccgcatgttcctgcgagtgctgctg
cacctgaccatgcacgactacccgtctcttgtctccggtgcgctgcagctgctcttcaaa
cacttcagccagcgccaggaagccatgcacactttcaagcaggtccagttgctgatctca
gcccaggatgtggagaactacaaggtgatcaagtcagagctggaccgactgcggacgatg
gtggagaagtcagagctgtgggtggacaagaaaggcagcgtcaagggcgaggaggttgag
gcaggcgccaccaaggataagaaggagagaccctcggacgaggagggatttctgcagcca
cacggggagaagagcagcgagaactaccagattgtgaaaggcatcctggagaggctgaac
aagatgtgtggggtgggggagcagatgaggaagaagcaacaaaggttgctgaagaacatg
gacgcccacaaggtcatgctggacctactgcagatcccttacgacaagagcgacaacaag
atgctggagatactgcgctacacacaccagttcctacagaagttctgtgctgggaaccct
ggcaaccaggcccttctgcacaaacacttgcagctcttcctcacgcctgggctcctggag
gctgagaccatgcagcacattttcctcaacaactaccagctgtgctctgagatcagcgag
ccggtgttgcaacactttgtgcacctgctggccacacacgggcgccatgtgcagtacttg
gacttcctgcacactgtcatcaaggctgagggcaagtacgtgaagaagtgccaggacatg
attatgaccgagctgaccaatgcaggtgacgacgtggtggtgttctacaacgacaaggcc
tctctggctcatctgttggacatgatgaaggcagccagagatggcgtggaggaccacagc
cctctcatgtatcacatctccctggtggacctgctggctgcctgtgcagagggcaagaac
gtctacacagagatcaagtgcacctccctcttgcctctagaggacgtggtgactgtggtc
acccacgaggattgtatcacggaggttaaaatggcttatgtgaacttcgtgaatcactgc
tacgtagacacggaggtggagatgaaggagatctacaccagcaaccacatctggacgctc
ttcgagaacttcaccctggacatggctctggtctgtaacaagcgggagaagcgcctgtca
gaccccacccttgagaagtacgtgctcaccgtggtcctggacaccatcagtgccttcttc
agctccccgttttcagagaacagcacatccctacagacgcaccagacaattgtggtccag
ctgctgcagtccaccacgcggctgctcgagtgtccttggctgcagcagcagcataagggc
tccgtggaggcctgtgtccgcaccctcgccatggtggccaagagtagagccatcttgctg
ccaatggatctggatgcccacatgagcgccctgctcagcagtgggggcagctgttccgcc
gctgcccagcgcagcgctgccaactacaagacggccaccaggaccttccctcgggtcatc
cccactgccaaccagtgggactacaagaacatcattgagaagttacaggatatcatcatg
gccctagaagagcggctgaagcctctggtacaggctgagctctctgtccttgtggacatg
ctgcactggcctgagctgctttttccagagggcagtgaggcctaccagcgctgcgagagc
gggggcttcctgtctaagctcatccgtcacactaagggtctcatggagtccgaggagaag
ttgtgcgtgaaggtgctgcggacgctgcagcagatgctgctgaagaagagcaagttcggg
gaccggggcaaccagctgcggaaaatgctgctgcagaattatctccagaaccgcaagtct
ggcgcccggggcgagctcactgaccccacgggctctggcctggatcaggactggtcagcc
atcgccgccacccagtgccggctggacaaggagggggccaccaagctggtgtgtgatctt
atcaccagcaccaagaacgagaagatcttccaggagagcattggcctggccatccgcctg
ctggacgggggcaacaccgagatccagaagtctttctacaacctgatgacaagtgacaag
aagtcggagcgcttcttcaaggtgcttcatgaccgcatgaagcgcgcccagcaggagacc
aagtccacggtcgctgtcaacatgagcgacctgggcagccagcctcgtgaggaccgggag
ccggcagatcctgccaccaaaggccgcgtgtcctccttctccatgcccagctcctcccgc
tatttgctgggcctcggcttgcaccgagggcacgacatgagcgagcgggcgcagaacaac
gagatggggacctcggtgctgatcatgcggcccatcctgcgcttcctgcagctgctgtgt
gagaaccacaaccgtgacctgcaaaacttcctgcgctgtcagaacaacaagaccaactac
aacctggtgtgtgagaccctgcagttcctggacatcatgtgtggcagcaccacagggggc
ctggggctgctggggctctacatcaacgaggacaacgtgggcctggtcatccagaccttg
gagaccctcacagagtactgccagggcccatgtcatgagaaccagacctgcattgtgact
cacgaatccaacggcatcgacatcatcacggcgctgatcctcaatgacatcagcccgctt
tgcaagtaccgcatggacctggtgctgcagctcaaggacaatgcctccaagctgctcctg
gctctgatggagagccgacatgacagtgagaatgcagagcgcatcctcatcagccttcgg
cctcaggagctggtggacgtgatcaagaaggcctacctgcaggaggaggagagggagaat
tcagaagtgagcccacgtgaagtgggccacaacatctacatcctagcactgcagctttcc
aggcacaacaagcagctgcagcacctgctgaagccagtgaggcgcatccaggaggaggag
gccgagggcatctcttccatgctcagcctcaacaataagcagctgtcccagatgctcaag
tcctcggcccccgcccaggaggaggaagaggacccgctggcctactatgagaatcacacc
tcgcagattgagattgtgcggcaagaccgaagcatggagcagatcgtgttcccggtacct
gccatctgccagttcctgacagaggagacgaagcaccggctcttcaccaccactgagcag
gacgagcagggcagcaaagtgagcgacttcttcgaccagtcctccttcctgcacaacgag
atggagtggcagcgccggcttcgcagcatgccgctcatctactggttctcccgccgcatg
acgctgtggggcagcatctccttcaacctggctgtgttcatcaatatcatcattgccttc
ttctacccctatgtggagggcgcttccacaggcgtgctgggctcgccgctcatctcgcta
ctcttctggatcctcatctgcttctccatcgctgcactgttcaccaagcgctacagcgtc
cgtcccctcatcgtggcgctgatccttcggtccatctactacctgggcattgggcccacg
ctcaacatcctgggtgctctcaatctgaccaacaagatcgtgtttgtggtgagcttcgtg
ggcaaccgtggcaccttcatccgaggctataaggccatggtcatggacatggagttcctg
taccatgtgggctacatcctgacaagcgtcctgggcctctttgcccatgagctcttctac
agcatcctgctctttgacctcatctaccgagaggagacgctgtttaatgtcatcaagagt
gtgacccgcaatggccgctccatcctactgaccgccctgctggccctcatccttgtgtac
ctcttctccatcgtgggcttcctcttcctcaaggacgacttcatcctggaggtggaccgg
ctgcccgggaaccactccagagccagccccctggggatgccacacggagctgccacattt
atgggcacatgtagtggggacaagatggactgtgtctctgaggtctcagtgcctgagatc
ctagaagaggacgaggagcccgatagcacggagcgggcctgtgacactctacttatgtgt
atcgtgaccgtcatgaaccacggactgaggaacggtggtggcgtgggcgacatcctccgc
aagccctccaaagatgagtcgctcttcccagccagagtggtgtatgaccttctgttcttc
tttatcgtcatcatcatcgtgttgaacctcatctttggggtgatcatcgacacctttgcc
gatctgcgcagcgagaagcagaagaaagaggaaatccttaagaccacgtgcttcatctgt
ggtctggagagggacaagtttgacaacaagacagtgtccttcgaggagcacatcaaactg
gagcataacatgtggaactacctgtacttcattgtactggtccgagtcaagaacaagaca
gactacaccggccccgagagctatgtggctcagatgatcaagaacaagaacctggactgg
ttcccgcggatgcgtgccatgtccctggtgagcggcgagggggagggggagcagaatgag
atccgcatcctgcaggagaagctcggctccaccatgaagctggtgtcgcacctcacctcc
cagctcaatgaactcaaggagcagatgacggagcagcggaaacggaggcagcgtctgggc
tttgtggatgtgcagaactgcatgagccgctga

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