KEGG   Mus musculus (mouse): 16451Help
Entry
16451             CDS       T01002                                 

Gene name
Jak1, AA960307, BAP004, C130039L05Rik
Definition
(RefSeq) Janus kinase 1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu04151  PI3K-Akt signaling pathway
mmu04217  Necroptosis
mmu04380  Osteoclast differentiation
mmu04550  Signaling pathways regulating pluripotency of stem cells
mmu04621  NOD-like receptor signaling pathway
mmu04630  Jak-STAT signaling pathway
mmu04658  Th1 and Th2 cell differentiation
mmu04659  Th17 cell differentiation
mmu05140  Leishmaniasis
mmu05145  Toxoplasmosis
mmu05152  Tuberculosis
mmu05160  Hepatitis C
mmu05161  Hepatitis B
mmu05162  Measles
mmu05163  Human cytomegalovirus infection
mmu05164  Influenza A
mmu05165  Human papillomavirus infection
mmu05166  Human T-cell leukemia virus 1 infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05168  Herpes simplex virus 1 infection
mmu05169  Epstein-Barr virus infection
mmu05200  Pathways in cancer
mmu05203  Viral carcinogenesis
mmu05212  Pancreatic cancer
mmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    16451 (Jak1)
   04151 PI3K-Akt signaling pathway
    16451 (Jak1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    16451 (Jak1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    16451 (Jak1)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    16451 (Jak1)
   04658 Th1 and Th2 cell differentiation
    16451 (Jak1)
   04659 Th17 cell differentiation
    16451 (Jak1)
  09158 Development
   04380 Osteoclast differentiation
    16451 (Jak1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    16451 (Jak1)
   05203 Viral carcinogenesis
    16451 (Jak1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    16451 (Jak1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    16451 (Jak1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    16451 (Jak1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    16451 (Jak1)
   05162 Measles
    16451 (Jak1)
   05164 Influenza A
    16451 (Jak1)
   05161 Hepatitis B
    16451 (Jak1)
   05160 Hepatitis C
    16451 (Jak1)
   05168 Herpes simplex virus 1 infection
    16451 (Jak1)
   05163 Human cytomegalovirus infection
    16451 (Jak1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    16451 (Jak1)
   05169 Epstein-Barr virus infection
    16451 (Jak1)
   05165 Human papillomavirus infection
    16451 (Jak1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    16451 (Jak1)
   05140 Leishmaniasis
    16451 (Jak1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    16451 (Jak1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    16451 (Jak1)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     16451 (Jak1)
Protein kinases [BR:mmu01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   16451 (Jak1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr Pkinase FERM_F2 Jak1_Phl FERM_F1 RIO1 SH2 FERM_M
Motif
Other DBs
NCBI-GeneID: 16451
NCBI-ProteinID: NP_038595
MGI: 96628
Ensembl: ENSMUSG00000028530
Vega: OTTMUSG00000008208
LinkDB All DBs
Position
4 C6; 4 46.19 cM
AA seq 1052 aa AA seqDB search
MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVVPEPGVEVTFYLLDREPLRLGSGEYTAEEL
CIRAAQECSISPLCHNLFALYDESTKLWYAPNRIITVDDKTSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKRVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENELS
RCHSNDSGNVLYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLEYNKHKKDDERNKLR
EEWNNFSYFPEITHIVIKESVVSINKQDNKNMELKLSSREEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSMDHFPSLRDLMNHLKKQILRTDNISFVLK
RCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGT
LLDYKDEEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL
LAREGIDSDIGPFIKLSDPGIPVSVLTRQDPDIVSEKQPTTEVDPTHFEKRFLKRIRDLG
EGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKG
ICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHR
DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIAS
DVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPD
EVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK
NT seq 3159 nt NT seq  +upstreamnt  +downstreamnt
atgcagtatctaaatataaaagaggactgcaatgccatggcgttctgtgctaaaatgagg
agcttcaagaagactgaggtgaagcaggtggtccctgagcctggagtggaggtgactttc
tatctgttggacagggagcccctccgcctgggcagcggagagtatacagccgaggagctg
tgcatcagggccgcccaggagtgcagtatctctcctctctgtcacaacctcttcgccctg
tacgatgagagcaccaagctctggtacgctccgaaccgaatcatcactgtggatgacaaa
acgtctctccggctccactaccgcatgaggttctactttaccaactggcacggaaccaat
gacaacgaacagtctgtatggcgacattctccaaagaagcagaaaaacggctatgagaag
aaaagggttccagaagcaaccccactccttgatgccagttcactggagtatctgtttgca
cagggacagtatgatttgatcaaatgcctggctcccattcgggaccccaagacggagcaa
gacggacatgatattgaaaatgagtgcctgggcatggcggtcctggccatctcccactat
gccatgatgaagaagatgcagttgccggaacttcccaaagacatcagctacaagcgatat
attccagaaacattgaataaatccatcagacagaggaaccttcttaccaggatgcgaata
aataatgttttcaaggatttcttgaaggaatttaacaacaagaccatctgtgacagcagt
gtgtctacacatgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat
tatggagctgaaatatttgagacttctatgctactgatttcatcagaaaatgaattgagt
cgatgccattcgaatgacagtggcaatgttctctatgaggtcatggtgactggaaatctc
gggatccagtggcggcagaaaccaaatgttgttcctgttgaaaaggaaaaaaataaactg
aagcggaaaaaactggaatataataaacacaagaaggatgatgagagaaacaaactccgg
gaagagtggaacaatttttcctatttccctgaaatcacccacattgtaataaaggagtct
gtggtcagcattaacaaacaggacaacaaaaacatggaactcaagctctcttctcgagag
gaagccttgtcctttgtgtccctggtggatggctacttccggctcactgcagatgcccac
cattacctctgtactgatgtggctcccccactgattgtccacaatatacagaacggctgc
cacggtccaatctgcacagaatatgccatcaataagctgcggcaggaagggagtgaagag
gggatgtacgtgctgaggtggagctgcaccgactttgacaacattcttatgactgtcacc
tgctttgaaaagtctgaggtattgggtggccagaagcagttcaagaactttcagattgag
gtacagaagggccgctacagcctgcatggctctatggaccactttcccagcctgcgagac
ctcatgaaccacctcaagaagcagatcctgcgcacggacaacataagctttgtgctgaaa
cgatgctgtcagcctaagcctcgagaaatctccaatctgctcgtagccactaagaaagcc
caggagtggcagcctgtctactccatgagccagctgagctttgatcggatccttaagaaa
gatattatacaaggtgagcaccttggcagaggcacaagaacacatatctattctgggacc
ctgctggactacaaggatgaggaaggaattgctgaagagaagaagataaaagtgatcctc
aaagtcctagaccccagccaccgggacatctctctggccttctttgaggctgctagcatg
atgagacaggtttcccacaaacatatagtgtacctctacggcgtgtgtgtccgagatgtg
gaaaatatcatggtggaagagtttgtggagggggggccgttggatctcttcatgcaccgg
aaaagtgatgcgcttactaccccctggaagttcaaggttgccaaacagctggccagtgcc
ctgagttacttggaagataaagacctggttcatggaaatgtgtgcactaaaaacctcctt
ctggcccgtgagggcattgacagtgacattggcccgttcatcaagcttagtgaccctggc
atcccagtctctgtgctgaccaggcaagatccagacattgtttcagaaaagcagccaaca
acagaggtggaccccactcactttgaaaagcggttcctgaagaggattcgtgacttggga
gagggtcactttgggaaggttgagctctgcagatatgatcctgagggagacaacacaggg
gagcaggtagctgtcaagtccctgaagcctgagagtggaggtaaccacatagctgatctg
aagaaggagatagagatcttacggaacctctaccatgagaacattgtgaagtacaaagga
atctgcatggaagacggaggcaatggtatcaagctcatcatggagtttctgccttcggga
agcctaaaggagtatctgccaaagaataagaacaaaatcaacctcaaacagcagctaaaa
tatgccatccagatttgtaaggggatggactacttgggttctcggcaatacgttcaccgg
gacttagcagcaagaaatgtccttgttgagagtgagcatcaagtgaagatcggagacttt
ggtttaaccaaagcaattgaaaccgataaggagtactacacagtcaaggacgaccgggac
agcccagtgttctggtacgctccggaatgtttaatccagtgtaaattttatatcgcctct
gatgtctggtcttttggagtgacactgcacgagctgctcacttactgtgactcagatttt
agtcccatggccttgttcctgaaaatgataggcccaactcatggccagatgacagtgaca
cggcttgtgaatactctgaaagaaggaaagcgtctgccatgtccacccaactgtcctgat
gaggtttatcagcttatgagaaaatgctgggaattccaaccatctaaccggacaactttt
cagaaccttattgaaggatttgaagcacttttaaaataa

KEGG   Mus musculus (mouse): 16452Help
Entry
16452             CDS       T01002                                 

Gene name
Jak2, Fd17
Definition
(RefSeq) Janus kinase 2
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu04062  Chemokine signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04217  Necroptosis
mmu04550  Signaling pathways regulating pluripotency of stem cells
mmu04630  Jak-STAT signaling pathway
mmu04658  Th1 and Th2 cell differentiation
mmu04659  Th17 cell differentiation
mmu04725  Cholinergic synapse
mmu04917  Prolactin signaling pathway
mmu04920  Adipocytokine signaling pathway
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu05140  Leishmaniasis
mmu05145  Toxoplasmosis
mmu05152  Tuberculosis
mmu05161  Hepatitis B
mmu05164  Influenza A
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05168  Herpes simplex virus 1 infection
mmu05200  Pathways in cancer
mmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    16452 (Jak2)
   04151 PI3K-Akt signaling pathway
    16452 (Jak2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    16452 (Jak2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    16452 (Jak2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    16452 (Jak2)
   04659 Th17 cell differentiation
    16452 (Jak2)
   04062 Chemokine signaling pathway
    16452 (Jak2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    16452 (Jak2)
   04917 Prolactin signaling pathway
    16452 (Jak2)
  09156 Nervous system
   04725 Cholinergic synapse
    16452 (Jak2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    16452 (Jak2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    16452 (Jak2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    16452 (Jak2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    16452 (Jak2)
  09172 Infectious disease: viral
   05164 Influenza A
    16452 (Jak2)
   05161 Hepatitis B
    16452 (Jak2)
   05168 Herpes simplex virus 1 infection
    16452 (Jak2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    16452 (Jak2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    16452 (Jak2)
   05140 Leishmaniasis
    16452 (Jak2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    16452 (Jak2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    16452 (Jak2)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     16452 (Jak2)
Protein kinases [BR:mmu01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   16452 (Jak2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 RIO1 Kinase-like FERM_M
Motif
Other DBs
NCBI-GeneID: 16452
NCBI-ProteinID: NP_001041642
MGI: 96629
Ensembl: ENSMUSG00000024789
UniProt: Q62120 G5E852
LinkDB All DBs
Structure
PDB: 

Position
19 C1; 19 23.73 cM
AA seq 1132 aa AA seqDB search
MGMACLTMTEMEATSTSPVHQNGDIPGSANSVKQIEPVLQVYLYHSLGQAEGEYLKFPSG
EYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHDILYRIRFYF
PHWYCSGSSRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKEKDQTPLAVYNSVSYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEQFEVKESARGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDVQLYCDFPDIIDVSIKQANQECSNESRIVTVHKQDGKVLEIELSSLK
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIHSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKRNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVQISPTLQRHNNVNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWA
MHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTEL
ANLINNCMDYEPDFRPAFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIE
LLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRVDQIRDSIAA
NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt
atgggaatggcctgccttacaatgacagaaatggaggcaacctccacatctcctgtacat
cagaatggtgatattcctggaagtgctaattctgtgaagcagatagagccagtccttcaa
gtgtatctgtaccattctcttgggcaagctgaaggagagtatctgaagtttccaagtgga
gagtatgttgcagaagaaatttgtgtggctgcttctaaagcttgtggtattacgcctgtg
tatcataatatgtttgcgttaatgagtgaaaccgaaaggatctggtacccacccaatcat
gtcttccacatagacgagtcaaccaggcatgacatactctacaggataaggttctacttc
cctcattggtactgtagtggcagcagcagaacctacagatacggagtgtcccgtggggct
gaagctcctctgcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat
tttgttcacggatggataaaagtacctgtgactcatgaaactcaggaagagtgtcttggg
atggcggtgttagacatgatgagaatagctaaggagaaagaccagactccactggctgtc
tataactctgtcagctacaagacattcttaccaaagtgcgttcgagcgaagatccaagac
tatcacattttaacccggaagcgaatcaggtacagatttcgcagattcattcagcaattc
agtcaatgtaaagccactgccaggaacctaaaacttaagtatcttataaacctggaaacc
ctgcagtctgccttctacacagaacagtttgaagtaaaagaatctgcaagaggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaggaaagtgagacactgacagaacaggacgtacagttatattgtgatttc
cctgatattattgatgtcagtattaagcaagcaaaccaggaatgctcaaatgaaagtaga
attgtaactgtccataaacaagatggtaaagttttggagatagaacttagctcattaaaa
gaagccttgtcattcgtgtcattaattgacgggtattacagactaactgcggatgcgcac
cattacctctgcaaagaggtggctcccccagctgtgctcgagaacatacacagcaactgc
cacggcccaatatcaatggattttgccattagcaaactaaagaaggcgggtaaccagact
ggactatatgtgctacgatgcagccctaaggacttcaacaaatactttctgacctttgct
gttgagcgagaaaatgtcattgaatataaacactgtttgattacgaagaatgagaatgga
gaatacaacctcagcgggactaagaggaacttcagtaaccttaaggaccttttgaattgc
taccagatggaaactgtgcgctcagacagtatcatcttccagtttaccaaatgctgcccc
ccaaagccaaaagataaatcaaaccttctcgtcttcagaacaaatggtatttctgatgtt
cagatctcaccaacattacagaggcataataatgtgaatcaaatggtgtttcacaaaatc
aggaatgaagatttaatatttaatgaaagtcttggccaaggtacttttacaaaaattttt
aaaggtgtaagaagagaagttggagattatggtcaactgcacaaaacggaagttcttttg
aaagtcctagataaagcacataggaactattcagagtctttcttcgaagcagcaagcatg
atgagtcagctttctcacaagcatttggttttgaattatggtgtctgtgtctgtggagag
gagaacattctggttcaagaatttgtaaaatttggatcactggatacatacctgaagaag
aacaaaaattccataaatatattatggaaacttggagtggctaagcagttggcatgggcc
atgcattttctagaagaaaaatcccttattcatgggaatgtgtgtgctaaaaatatcctg
cttatcagagaagaagacaggagaacggggaacccacctttcatcaaacttagtgatcct
ggcattagcattacagttctaccgaaggacattcttcaggagagaataccatgggtacct
cctgaatgcattgagaatcctaaaaatctcaatctggcaacagacaagtggagcttcggg
accactctgtgggagatctgcagtggaggagataagcccctgagtgctctggattctcaa
agaaagctgcagttctatgaagataagcatcagcttcctgcacccaagtggacagagtta
gcaaaccttataaataattgcatggactatgagccagatttcaggcctgctttcagagct
gtcatccgtgatcttaacagcctgtttactccagattatgaactactaacagaaaatgac
atgctaccaaacatgagaataggtgccctagggttttctggtgcttttgaagacagggac
cctacacagtttgaagagagacacttgaagtttctacagcagcttggcaaaggtaacttc
gggagtgtggagatgtgccgctatgacccgctgcaggacaacactggcgaggtggtcgct
gtgaagaaactccagcacagcactgaagagcacctccgagactttgagagggagatcgag
atcctgaaatccttgcagcatgacaacatcgtcaagtacaagggagtgtgctacagtgcg
ggtcggcgcaacctaagattaattatggaatatttaccatatggaagtttacgagactat
ctccaaaaacataaagaacggatagatcacaaaaaacttcttcaatacacatctcagata
tgcaagggcatggaatatcttggtacaaaaaggtatatccacagggacctggcaacaagg
aacatattggtggaaaatgagaacagggttaaaataggagacttcggattaaccaaagtc
ttgccgcaggacaaagaatactacaaagtaaaggagccaggggaaagccccatattctgg
tacgcacctgaatccttgacggagagcaagttttctgtggcctcagatgtgtggagcttt
ggagtggttctatacgaacttttcacatacatcgagaagagtaaaagtccacccgtggaa
tttatgcgaatgattggcaatgataaacaagggcaaatgattgtgttccatttgatagag
ctactgaagagcaacggaagattgccaaggccagaaggatgcccagatgagatttatgtg
atcatgacagagtgctggaacaacaatgtgagccagcgtccctccttcagggacctttcc
cttcgggtggatcaaatccgggacagtatagctgcgtga

KEGG   Mus musculus (mouse): 16453Help
Entry
16453             CDS       T01002                                 

Gene name
Jak3, fae, wil
Definition
(RefSeq) Janus kinase 3
  KO
K11218  Janus kinase 3 [EC:2.7.10.2]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04062  Chemokine signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04217  Necroptosis
mmu04550  Signaling pathways regulating pluripotency of stem cells
mmu04630  Jak-STAT signaling pathway
mmu04658  Th1 and Th2 cell differentiation
mmu04659  Th17 cell differentiation
mmu05161  Hepatitis B
mmu05162  Measles
mmu05166  Human T-cell leukemia virus 1 infection
mmu05169  Epstein-Barr virus infection
mmu05200  Pathways in cancer
mmu05203  Viral carcinogenesis
mmu05223  Non-small cell lung cancer
mmu05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    16453 (Jak3)
   04151 PI3K-Akt signaling pathway
    16453 (Jak3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    16453 (Jak3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    16453 (Jak3)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    16453 (Jak3)
   04659 Th17 cell differentiation
    16453 (Jak3)
   04062 Chemokine signaling pathway
    16453 (Jak3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    16453 (Jak3)
   05203 Viral carcinogenesis
    16453 (Jak3)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    16453 (Jak3)
  09163 Immune disease
   05340 Primary immunodeficiency
    16453 (Jak3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    16453 (Jak3)
   05162 Measles
    16453 (Jak3)
   05161 Hepatitis B
    16453 (Jak3)
   05169 Epstein-Barr virus infection
    16453 (Jak3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    16453 (Jak3)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     16453 (Jak3)
Protein kinases [BR:mmu01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   16453 (Jak3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr Pkinase FERM_F2 FERM_F1 Jak1_Phl APH Kdo pKID Haspin_kinase
Motif
Other DBs
NCBI-GeneID: 16453
NCBI-ProteinID: NP_001177759
MGI: 99928
Ensembl: ENSMUSG00000031805
Vega: OTTMUSG00000021111
UniProt: Q62137 A0A0R4J0R7
LinkDB All DBs
Position
8 B3.3; 8 34.43 cM
AA seq 1100 aa AA seqDB search
MAPPSEETPLIPQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDYLAEDLCVRAAKA
CGILPVYHSLFALATEDFSCWFPPSHIFCIEDVDTQVLVYRLRFYFPDWFGLETCHRFGL
RKDLTSAILDLHVLEHLFAQHRSDLVSGRLPVGLSMKEQGEFLSLAVLDLAQMAREQAQR
PGELLKTVSYKACLPPSLRDVIQGQNFVTRRRIRRTVVLALRRVVACQADRYALMAKYIL
DLERLHPAATTETFRVGLPGAQEEPGLLRVAGDNGISWSSGDQELFQTFCDFPEIVDVSI
KQAPRVGPAGEHRLVTVTRMDGHILEAEFPGLPEALSFVALVDGYFRLICDSRHYFCKEV
APPRLLEEEAELCHGPITLDFAIHKLKAAGSLPGTYILRRSPQDYDSFLLTACVQTPLGP
DYKGCLIRQDPSGAFSLVGLSQPHRSLRELLAACWNSGLRVDGAALNLTSCCAPRPKEKS
NLIVVRRGCTPAPAPGCSPSCCALTQLSFHTIPTDSLEWHENLGHGSFTKIFRGRRREVV
DGETHDSEVLLKVMDSRHRNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVY
LGAIDMYLRKRGHLVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNP
PFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEAQTLGLEADKWGFGATTWEVFSGGPA
HITSLEPAKKLKFYEDQGQLPALKWTELAGLITQCMAYDPGRRPSFRAILRDLNGLITSD
YELLSDPTPGIPSPRDELCGGAQLYACQDPAIFEERHLKYISLLGKGNFGSVELCRYDPL
GDNTGPLVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEY
LPSGCLRDFLQRHRARLHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVK
IADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYC
DKSCSPSAEFLSMMGPEREGPPLCRLLELLAEGRRLPPPPTCPTEVQELMQLCWAPSPHD
RPAFGTLSPQLDALWRGRPG
NT seq 3303 nt NT seq  +upstreamnt  +downstreamnt
atggcacctccaagtgaggagacacctctgatccctcagcgctcttgcagcctctcatcc
tcagaggcaggagccctgcatgtgctccttcctccccggggacctgggcctccccagcga
ttgtcattctcttttggggactacttggctgaggatttatgtgtgcgagctgccaaggcc
tgtggcatcctgcctgtttatcattcgcttttcgctctggccactgaggacttctcttgc
tggtttcccccaagccacatcttctgcatagaggacgtggacactcaagtcttggtctac
aggctacgcttttatttccctgactggtttgggctggagacatgtcaccgctttgggctg
cgcaaagatttgaccagtgccatccttgacttacacgttttagaacatctctttgctcag
caccgcagtgacctggtgagtgggcgcctcccggtgggccttagcatgaaggagcaggga
gagttcctgagcctggccgtgctggacttggcccagatggctcgtgagcaggcccagcgc
ccaggagagctgctgaagacggtcagttacaaagcctgtctgccgcccagcctgcgcgat
gtgatccagggccagaacttcgtgacacgcaggcgcatccgcaggaccgtggtcttggcg
ctgcgccgtgtggtcgcctgccaggccgaccgctacgcgctcatggccaagtatattttg
gacctggagcggctacatccagcggccaccaccgagaccttccgtgtggggctcccgggc
gcccaggaggagccggggcttctgcgtgtggcgggggacaacggcatctcctggagctcc
ggggaccaggagcttttccagaccttctgtgactttccggaaatcgtggatgtcagcatc
aagcaggccccacgtgtgggtccggcaggggaacaccggctggtcaccgtcaccaggatg
gacggccacatcctggaagcggagtttccggggctgcctgaggcgctgtccttcgtggcc
cttgtggatgggtacttccgcctgatctgcgactccaggcattatttctgcaaggaggtg
gcgccgccgcggctgctggaggaggaggcggagctgtgccatggacccatcacgttagac
tttgccatccacaagctgaaggccgctggctccctcccaggcacctacattctccgccgc
agcccgcaggactatgacagctttcttcttaccgcctgcgtccagactcctcttggcccc
gactacaagggctgcctcatccgccaggaccccagcggggctttctccctggttggcctc
agccagccccacagaagcctgcgggagctgcttgcagcctgctggaattctgggctgcga
gtagacggtgctgccctgaacctaacatcctgctgcgctcccagacccaaggaaaagtcc
aatttgatcgtggtgcgaaggggctgcacccccgcgcctgcccctggctgctccccgtcc
tgctgtgcgctgacacagctgagcttccacacaattccaacggacagcctggagtggcac
gagaacctgggtcacggttcttttaccaagatcttccgtggccgcaggcgggaggtcgtg
gatggtgagacacatgactcggaagtcctcctgaaggtcatggactccagacatcggaac
tgcatggagtcttttctggaagccgcaagcttgatgagccaagtatcctacccgcacctg
gtgttactgcacggcgtctgcatggctggagacagcatcatggtgcaggaatttgtgtat
ctaggagcaattgacatgtacctgcgcaagcgtggccacctggtgtcagccagctggaaa
ctgcaggtgaccaagcagctggcatatgcccttaactacttggaggacaaaggccttcct
cacggcaacgtctcagcacggaaggtgctcctggctcgtgaggggggtgatgggaatcca
cctttcattaagctgagtgatcctggtgtcagtcccactgtgctgagcctggaaatgctc
accgacagaataccctgggtggcccccgaatgtctccaggaggctcagacactcggcttg
gaggctgacaagtggggctttggagccaccacgtgggaggtgttcagcgggggacccgcc
cacatcacctcgctggagcccgccaaaaagctgaagttctatgaggaccagggacagctg
cccgctctcaaatggacagaactggcgggacttatcacacagtgcatggcctatgatcct
ggccggcgcccctccttccgagctatcctcagagacctcaacggcctcattacatcagat
tacgagctcctctcagaccccacacctggcatcccgagtcctcgagatgagctgtgcggt
ggcgcccagctctatgcctgccaggaccccgccatattcgaggagagacaccttaagtac
atctctttgctgggcaagggcaactttggcagcgtggagctgtgccgctatgaccccctg
ggggacaatacgggacccctggtggcagtgaaacagctacagcacagcgggccagaccag
cagagggacttccagcgggagattcagatccttaaggctctgcacagcgacttcatcgtc
aagtaccggggagtcagctatgggccaggtcgccagagcctgcggttggtgatggagtac
ctgcccagcggctgcctgcgagacttcctgcagcgccatcgcgcgcgcctgcacaccgac
cgcctactgctgttcgcttggcagatctgcaagggcatggagtacctgggtgcgcgccgc
tgcgtacaccgtgacctggctgcgcgcaacatcttggtggagagcgaggctcatgtgaag
atcgcggacttcggcctcgctaagctgctgcccctgggaaaggactactacgtggtccgc
gagcctggccaaagccccatcttttggtatgccccggagtccctatctgacaacatcttc
tcccgccaatctgacgtgtggagcttcggagtggtgttgtacgagctcttcacctactgc
gacaagagctgcagcccatccgctgagttcctgagcatgatggggcctgagcgtgaagga
cccccgctctgccgcctcctggagctgctggcagagggccgacgcctcccaccacctccc
acctgccccaccgaggttcaggagctcatgcagctgtgctgggcgcccagcccgcacgac
cggccagccttcggcaccctgagcccccagctggacgcgctgtggcgtggaagacccgga
tag

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