KEGG   Mus musculus (mouse): 18033Help
Entry
18033             CDS       T01002                                 

Gene name
Nfkb1, NF-KB1, NF-kappaB, NF-kappaB1, p105, p50, p50/p105
Definition
(RefSeq) nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
  KO
K02580  nuclear factor NF-kappa-B p105 subunit
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01523  Antifolate resistance
mmu04010  MAPK signaling pathway
mmu04014  Ras signaling pathway
mmu04024  cAMP signaling pathway
mmu04062  Chemokine signaling pathway
mmu04064  NF-kappa B signaling pathway
mmu04066  HIF-1 signaling pathway
mmu04071  Sphingolipid signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04210  Apoptosis
mmu04211  Longevity regulating pathway
mmu04218  Cellular senescence
mmu04380  Osteoclast differentiation
mmu04620  Toll-like receptor signaling pathway
mmu04621  NOD-like receptor signaling pathway
mmu04622  RIG-I-like receptor signaling pathway
mmu04623  Cytosolic DNA-sensing pathway
mmu04625  C-type lectin receptor signaling pathway
mmu04657  IL-17 signaling pathway
mmu04658  Th1 and Th2 cell differentiation
mmu04659  Th17 cell differentiation
mmu04660  T cell receptor signaling pathway
mmu04662  B cell receptor signaling pathway
mmu04668  TNF signaling pathway
mmu04722  Neurotrophin signaling pathway
mmu04917  Prolactin signaling pathway
mmu04920  Adipocytokine signaling pathway
mmu04926  Relaxin signaling pathway
mmu04931  Insulin resistance
mmu04932  Non-alcoholic fatty liver disease (NAFLD)
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu05030  Cocaine addiction
mmu05132  Salmonella infection
mmu05133  Pertussis
mmu05134  Legionellosis
mmu05135  Yersinia infection
mmu05140  Leishmaniasis
mmu05142  Chagas disease (American trypanosomiasis)
mmu05145  Toxoplasmosis
mmu05146  Amoebiasis
mmu05152  Tuberculosis
mmu05160  Hepatitis C
mmu05161  Hepatitis B
mmu05162  Measles
mmu05163  Human cytomegalovirus infection
mmu05164  Influenza A
mmu05165  Human papillomavirus infection
mmu05166  Human T-cell leukemia virus 1 infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05168  Herpes simplex virus 1 infection
mmu05169  Epstein-Barr virus infection
mmu05170  Human immunodeficiency virus 1 infection
mmu05200  Pathways in cancer
mmu05202  Transcriptional misregulation in cancer
mmu05203  Viral carcinogenesis
mmu05206  MicroRNAs in cancer
mmu05212  Pancreatic cancer
mmu05215  Prostate cancer
mmu05220  Chronic myeloid leukemia
mmu05221  Acute myeloid leukemia
mmu05222  Small cell lung cancer
mmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmu05321  Inflammatory bowel disease (IBD)
mmu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    18033 (Nfkb1)
   04010 MAPK signaling pathway
    18033 (Nfkb1)
   04064 NF-kappa B signaling pathway
    18033 (Nfkb1)
   04668 TNF signaling pathway
    18033 (Nfkb1)
   04066 HIF-1 signaling pathway
    18033 (Nfkb1)
   04071 Sphingolipid signaling pathway
    18033 (Nfkb1)
   04024 cAMP signaling pathway
    18033 (Nfkb1)
   04151 PI3K-Akt signaling pathway
    18033 (Nfkb1)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    18033 (Nfkb1)
   04218 Cellular senescence
    18033 (Nfkb1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    18033 (Nfkb1)
   04621 NOD-like receptor signaling pathway
    18033 (Nfkb1)
   04622 RIG-I-like receptor signaling pathway
    18033 (Nfkb1)
   04623 Cytosolic DNA-sensing pathway
    18033 (Nfkb1)
   04625 C-type lectin receptor signaling pathway
    18033 (Nfkb1)
   04660 T cell receptor signaling pathway
    18033 (Nfkb1)
   04658 Th1 and Th2 cell differentiation
    18033 (Nfkb1)
   04659 Th17 cell differentiation
    18033 (Nfkb1)
   04657 IL-17 signaling pathway
    18033 (Nfkb1)
   04662 B cell receptor signaling pathway
    18033 (Nfkb1)
   04062 Chemokine signaling pathway
    18033 (Nfkb1)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    18033 (Nfkb1)
   04917 Prolactin signaling pathway
    18033 (Nfkb1)
   04926 Relaxin signaling pathway
    18033 (Nfkb1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    18033 (Nfkb1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    18033 (Nfkb1)
  09149 Aging
   04211 Longevity regulating pathway
    18033 (Nfkb1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    18033 (Nfkb1)
   05202 Transcriptional misregulation in cancer
    18033 (Nfkb1)
   05206 MicroRNAs in cancer
    18033 (Nfkb1)
   05203 Viral carcinogenesis
    18033 (Nfkb1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    18033 (Nfkb1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    18033 (Nfkb1)
   05221 Acute myeloid leukemia
    18033 (Nfkb1)
   05220 Chronic myeloid leukemia
    18033 (Nfkb1)
   05215 Prostate cancer
    18033 (Nfkb1)
   05222 Small cell lung cancer
    18033 (Nfkb1)
  09163 Immune disease
   05321 Inflammatory bowel disease (IBD)
    18033 (Nfkb1)
  09165 Substance dependence
   05030 Cocaine addiction
    18033 (Nfkb1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    18033 (Nfkb1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    18033 (Nfkb1)
   04931 Insulin resistance
    18033 (Nfkb1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    18033 (Nfkb1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    18033 (Nfkb1)
   05135 Yersinia infection
    18033 (Nfkb1)
   05133 Pertussis
    18033 (Nfkb1)
   05134 Legionellosis
    18033 (Nfkb1)
   05152 Tuberculosis
    18033 (Nfkb1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    18033 (Nfkb1)
   05170 Human immunodeficiency virus 1 infection
    18033 (Nfkb1)
   05162 Measles
    18033 (Nfkb1)
   05164 Influenza A
    18033 (Nfkb1)
   05161 Hepatitis B
    18033 (Nfkb1)
   05160 Hepatitis C
    18033 (Nfkb1)
   05168 Herpes simplex virus 1 infection
    18033 (Nfkb1)
   05163 Human cytomegalovirus infection
    18033 (Nfkb1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    18033 (Nfkb1)
   05169 Epstein-Barr virus infection
    18033 (Nfkb1)
   05165 Human papillomavirus infection
    18033 (Nfkb1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    18033 (Nfkb1)
   05145 Toxoplasmosis
    18033 (Nfkb1)
   05140 Leishmaniasis
    18033 (Nfkb1)
   05142 Chagas disease (American trypanosomiasis)
    18033 (Nfkb1)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    18033 (Nfkb1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:mmu03000]
    18033 (Nfkb1)
Transcription factors [BR:mmu03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Rel/Ankyrin
    18033 (Nfkb1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: RHD_DNA_bind RHD_dimer Ank_2 Ank_4 Ank Ank_5 Ank_3 Death
Motif
Other DBs
NCBI-GeneID: 18033
NCBI-ProteinID: NP_032715
MGI: 97312
Ensembl: ENSMUSG00000028163
Vega: OTTMUSG00000016668
UniProt: P25799
LinkDB All DBs
Structure
PDB: 

Position
3 G3; 3 62.82 cM
AA seq 971 aa AA seqDB search
MADDDPYGTGQMFHLNTALTHSIFNAELYSPEIPLSTDGPYLQILEQPKQRGFRFRYVCE
GPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGV
CTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHSDLAYLQAEG
GGDRQLTDREKEIIRQAAVQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDS
KAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSP
TDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRK
RQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPG
VTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALA
STMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGD
SVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRV
GADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSL
PCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLH
IAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQV
FDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGIL
NNAFRLSPAPSKTLMDNYEVSGGTIKELMEALQQMGYTEAIEVIQAAFRTPATTASSPVT
TAQVHCLPLSSSSTRQHIDELRDSDSVCDSGVETSFRKLSFTESLTGDSPLLSLNKMPHG
YGQEGPIEGKI
NT seq 2916 nt NT seq  +upstreamnt  +downstreamnt
atggcagacgatgatccctacggaactgggcaaatgtttcatttgaacactgctttgact
cactcaatatttaatgcagaattatattcaccagaaataccactgtcaacagatggccca
taccttcaaatattagagcaaccaaaacagaggggatttcgattccgctatgtgtgtgaa
ggcccatcacacggagggcttccgggagcctctagtgagaagaacaagaaatcctaccca
caggtcaaaatttgcaactatgtggggcctgcaaaggttatcgttcagttggtcacaaat
ggaaaaaacatccacctgcacgcccacagcctggtgggcaagcactgtgaggacggggta
tgcaccgtaacagcaggacccaaggacatggtggttggctttgcaaacctgggaatactt
catgtgactaagaaaaaggtatttgaaacactggaagcacggatgacagaggcgtgtatt
aggggctataatcctggacttctggtgcattctgaccttgcctatctacaagcagaaggc
ggaggagaccggcaactcacagacagagagaaggagatcatccgccaggcagccgtgcag
cagaccaaggagatggacctgagcgtggtgcgcctcatgttcacagccttcctccctgac
agcactggcagcttcactcggagactggagcctgtggtgtcagacgccatctatgatagc
aaagccccgaatgcatccaacctgaaaatcgtgagaatggacagaacagcaggatgtgtg
acgggaggggaggagatttaccttctctgtgacaaggttcagaaagatgacatccagatt
cggttttatgaagaggaagaaaatggcggagtttgggaaggatttggggacttttccccc
acagatgttcatagacagtttgccattgtcttcaaaacgccaaagtataaggatgtcaac
attacaaagccagcttccgtgtttgttcagcttcggaggaaatcagacctggaaactagt
gaaccgaaaccctttctctactaccctgaaatcaaagacaaagaggaagtgcaaaggaaa
cgccagaagcttatgccgaacttctcggacagcttcggtggcggcagtggagcgggagcc
ggtggtggaggcatgttcggtagtggcggtggcggagggagtaccggaagccctggccca
gggtatggctactcgaactacggatttcctccctacggtgggattacattccatcccgga
gtcacgaaatccaacgcaggggtcacccatggcaccataaacaccaaatttaaaaatggc
cctaaagattgtgccaagagtgatgacgaggagagtctgactctccctgagaaggaaact
gaaggtgaagggcccagcctgcccatggcctgcaccaagacggaacccatcgccttggca
tccaccatggaagacaaggagcaggacatgggatttcaggataacctctttcttgagaag
gctctgcagctcgccaggcgacacgccaacgcccttttcgactacgcagtgacgggggat
gtgaagatgttgctggccgtgcaacgccatctcaccgccgtgcaggatgagaatggggac
agtgtcttacacttagccatcatccacctccacgctcagcttgtgagggatctgctggaa
gtcacatctggtttgatctctgatgacatcatcaacatgagaaatgacctgtatcagaca
cctctgcacttggccgtgatcaccaagcaggaagatgtagtagaggatttgctgagggtt
ggggctgacctgagccttctggaccgctggggcaactctgtcctgcacctagctgccaaa
gaaggacacgacagaatcctcagcatcctgctcaagagcagaaaagcagcgccccttatc
gaccaccccaatggggaaggtctaaatgccatccacatagctgtgatgagcaatagcctg
ccatgtctgctgctgctggtggctgccggggcagaagtcaatgctcaggagcagaagtct
gggcgcacagcgctgcacctggccgtggagtacgacaacatctccttggctggctgcctg
cttctggagggtgatgcccacgtggacagtaccacctatgatgggactacacctctgcat
atagcggccggaagagggtccaccagactggcagctcttctcaaagcagcaggagcagac
cccctggtggagaactttgagcctctctatgacctggacgactcttgggagaaggctgga
gaagatgagggagtggtgccaggtaccacacccctggacatggctgccaactggcaggta
tttgacatactaaatgggaaaccgtatgagcctgtgttcacatctgatgatatactacca
caaggggacatgaagcagctgacagaagacacgaggctacaactctgcaaactgctggaa
attcctgatccagacaaaaactgggccactctggcacagaagttgggtctggggatactg
aacaatgccttccggctgagtcctgctccttctaaaactctcatggacaactatgaggtc
tctgggggtaccatcaaagagctgatggaggccctgcaacagatgggctacacagaggcc
attgaagtgatccaggcagccttccgcaccccggcaaccacagcctccagccccgtgacc
actgctcaggtccactgtctgcctctctcgtcttcctccacgaggcagcacatagatgaa
ctccgggatagtgacagcgtctgtgacagtggtgtggagacatccttccgcaaactcagc
tttacagagtctcttactggagacagcccactgctatctctgaacaaaatgccccacggt
tatgggcaggaaggacctattgaaggcaaaatttag

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