KEGG   PATHWAY: mna04540
Entry
mna04540                    Pathway                                

Name
Gap junction - Miniopterus natalensis
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mna04540  Gap junction
mna04540

Other DBs
GO: 0005921
Organism
Miniopterus natalensis [GN:mna]
Gene
107536808  GJA1; gap junction alpha-1 protein [KO:K07372]
107542976  GJD2; gap junction delta-2 protein [KO:K07373]
107537650  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
107545320  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
107540752  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
107545079  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
107543141  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
107531241  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
107527538  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
107532411  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
107534373  EGF; pro-epidermal growth factor [KO:K04357]
107532710  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
107535230  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
107525996  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107536618  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
107525851  SOS2; son of sevenless homolog 2 [KO:K03099]
107541780  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
107542351  HRAS; GTPase HRas isoform X1 [KO:K02833]
107525258  KRAS; GTPase KRas [KO:K07827]
107545303  NRAS; GTPase NRas [KO:K07828]
107534729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107533801  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107525695  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107541504  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107530451  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107542143  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
107528582  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
107525835  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
107524519  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
107530489  tubulin alpha-3 chain [KO:K07374]
107542424  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
107528244  tubulin alpha-1B chain-like [KO:K07374]
107528245  tubulin alpha-1B chain isoform X1 [KO:K07374]
107528246  tubulin alpha-1B chain isoform X1 [KO:K07374]
107524780  TUBA4A; tubulin alpha-4A chain [KO:K07374]
107524054  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
107524827  tubulin alpha-1D chain-like [KO:K07374]
107541660  tubulin alpha-1C chain-like [KO:K07374]
107525187  TUBB6; tubulin beta-6 chain [KO:K07375]
107529811  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
107525682  TUBB4A; tubulin beta-4A chain [KO:K07375]
107536203  TUBB4B; tubulin beta-4B chain [KO:K07375]
107538495  TUBB; tubulin beta chain [KO:K07375]
107540743  tubulin beta-2B chain [KO:K07375]
107536539  TUBB3; tubulin beta-3 chain [KO:K07375]
107539077  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
107543348  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
107527961  TJP1; tight junction protein ZO-1 [KO:K05701]
107536422  ADRB1; beta-1 adrenergic receptor [KO:K04141]
107533905  DRD1; D(1A) dopamine receptor [KO:K04144]
107529329  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
107529353  neuroendocrine secretory protein 55-like [KO:K04632]
107531298  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
107526004  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
107540528  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
107534062  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
107531740  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
107527242  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
107528232  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
107531029  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
107539500  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
107535777  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
107544336  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107543188  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107537524  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
107530766  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
107526926  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
107532400  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
107544328  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
107544926  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
107542967  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
107536366  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
107536369  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
107539797  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
107529142  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
107525255  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
107541588  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
107538300  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107544745  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
107540426  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
107527534  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
107532921  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
107527535  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
107537733  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
107543282  PRKG1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
107537152  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
mna04010  MAPK signaling pathway
mna04020  Calcium signaling pathway
mna04060  Cytokine-cytokine receptor interaction
mna04070  Phosphatidylinositol signaling system
mna04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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