Entry
Name
GABAergic synapse - Miniopterus natalensis (Natal long-fingered bat)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:
mna ]
Gene
107528214 SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990 ]
107528216 SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207 ]
107537889 GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175 ]
107537965 GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 isoform X1 [KO:K05175 ]
107537858 GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175 ]
107527865 GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175 ]
107532500 GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 [KO:K05175 ]
107533097 GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175 ]
107528034 GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181 ]
107537880 GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181 ]
107533104 GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181 ]
107537863 GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186 ]
107527855 GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186 ]
107532484 GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 isoform X1 [KO:K05186 ]
107540159 GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184 ]
107537955 LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit epsilon-like [KO:K05185 ]
107537964 GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192 ]
107524724 GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
107544101 GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
107544523 GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341 ]
107530892 SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967 ]
107533430 GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190 ]
107533431 GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190 ]
107527103 GABRR3; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190 ]
107541038 CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344 ]
107536136 CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849 ]
107546425 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
107534931 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
107541372 CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853 ]
107536018 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
107544719 GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615 ]
107545035 GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615 ]
107545320 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
107540752 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
107545079 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
107543463 GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
107540160 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
107540939 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
107544078 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
107541113 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
107546541 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
107525867 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
107543109 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
107527185 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
107543194 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
107534609 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
107536795 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
107541861 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
107537622 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545 ]
107541673 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
107541527 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347 ]
107533406 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
107533363 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
107541750 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
107539173 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
107543277 KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000 ]
107534769 SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034 ]
107546420 SLC6A13; sodium- and chloride-dependent GABA transporter 2 [KO:K05046 ]
107534685 SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044 ]
107546421 SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045 ]
107529400 SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576 ]
107541391 SLC38A5; sodium-coupled neutral amino acid transporter 5 [KO:K14992 ]
Compound
Reference
Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
Title
Neuropsychopharmacology: The fifth generation of progress
Journal
Reference
Authors
Farrant M, Kaila K
Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
Journal
Reference
Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
Journal
Reference
Authors
Pinard A, Seddik R, Bettler B
Title
GABAB receptors: physiological functions and mechanisms of diversity.
Journal
Reference
Authors
Chalifoux JR, Carter AG
Title
GABAB receptor modulation of synaptic function.
Journal
Reference
Authors
Padgett CL, Slesinger PA
Title
GABAB receptor coupling to G-proteins and ion channels.
Journal
Reference
Authors
Emson PC
Title
GABA(B) receptors: structure and function.
Journal
Reference
Authors
Kornau HC
Title
GABA(B) receptors and synaptic modulation.
Journal
Reference
Authors
Jacob TC, Moss SJ, Jurd R
Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
Journal
Reference
Authors
Kneussel M
Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
Journal
Reference
Authors
Luscher B, Fuchs T, Kilpatrick CL
Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
Journal
Reference
Authors
Arancibia-Carcamo IL, Kittler JT
Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
Journal
Reference
Authors
Bak LK, Schousboe A, Waagepetersen HS
Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
Journal
Reference
Authors
Conti F, Minelli A, Melone M
Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
Journal
Reference
Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
Title
GABAergic dysfunction in mood disorders.
Journal
Reference
Authors
Chebib M, Johnston GA
Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
Journal
Related pathway
mna00250 Alanine, aspartate and glutamate metabolism
KO pathway
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