KEGG   PATHWAY: mna04914
mna04914                    Pathway                                

Progesterone-mediated oocyte maturation - Miniopterus natalensis
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Organismal Systems; Endocrine system
Pathway map
mna04914  Progesterone-mediated oocyte maturation

Other DBs
GO: 0001556
Miniopterus natalensis [GN:mna]
107532393  PGR; progesterone receptor [KO:K08556]
107526728  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107529317  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107535325  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107532628  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:]
107538463  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:]
107541106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:]
107537133  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:]
107527953  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:]
107528432  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:]
107545565  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:]
107545613  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:]
107536041  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:]
107536051  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:]
107545320  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
107540752  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
107545079  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
107526004  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:]
107540528  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:]
107534062  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:]
107531740  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:]
107527242  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:]
107528232  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:]
107531029  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:]
107539500  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:]
107535777  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:]
107544336  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
107543188  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:]
107538079  AURKA; aurora kinase A [KO:K11481] [EC:]
107539248  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
107533909  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
107530440  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
107543254  CPEB3; cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
107533551  SPDYC; speedy protein C [KO:K08694]
107534707  SPDYA; speedy protein A isoform X1 [KO:K08694]
107525454  putative speedy protein-like protein 3 [KO:K08694]
107537580  speedy protein E4-like [KO:K08694]
107538223  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:]
107543348  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:]
107525165  CCNA1; cyclin-A1 [KO:K06627]
107528451  CCNA2; cyclin-A2 [KO:K06627]
107533158  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:]
107536915  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
107536502  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
107533801  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:]
107541504  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:]
107530451  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:]
107526793  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:]
107532955  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:]
107530622  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:]
107539953  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:]
107535809  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:]
107537801  CCNB1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
107533754  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
107541465  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
107535713  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:]
107544743  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:]
107529418  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:]
107536397  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:]
107530121  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:]
107545147  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
107527774  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
107546709  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:]
107525258  KRAS; GTPase KRas [KO:K07827]
107541381  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:]
107531103  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:]
107534729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:]
107528688  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:]
107537043  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
107528423  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
107540988  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
107525625  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
107539636  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
107536147  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
107530322  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
107541233  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
107529590  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
107523893  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
107529596  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
107530120  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
107532521  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
107539093  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
107535457  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
107546107  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
107541498  KIF22; kinesin-like protein KIF22 [KO:K10403]
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Schmitt A, Nebreda AR.
Signalling pathways in oocyte meiotic maturation.
J Cell Sci 115:2457-9 (2002)
Cato AC, Nestl A, Mink S.
Rapid actions of steroid receptors in cellular signaling pathways.
Sci STKE 2002:RE9 (2002)
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Biol Cell 93:27-33 (2001)
Nebreda AR, Ferby I.
Regulation of the meiotic cell cycle in oocytes.
Curr Opin Cell Biol 12:666-75 (2000)
Ferrell JE Jr.
Xenopus oocyte maturation: new lessons from a good egg.
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Biochem J 369:227-38 (2003)
Duckworth BC, Weaver JS, Ruderman JV.
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Proc Natl Acad Sci U S A 99:16794-9 (2002)
Abrieu A, Doree M, Fisher D.
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
J Cell Sci 114:257-67 (2001)
mna04010  MAPK signaling pathway
mna04110  Cell cycle
KO pathway

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