KEGG   PATHWAY: mna04962
mna04962                    Pathway                                

Vasopressin-regulated water reabsorption - Miniopterus natalensis
In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again.
Organismal Systems; Excretory system
Pathway map
mna04962  Vasopressin-regulated water reabsorption

Miniopterus natalensis [GN:mna]
107536288  AVP; vasopressin-neurophysin 2-copeptin [KO:K05242]
107538807  AVPR2; vasopressin V2 receptor [KO:K04228]
107529329  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
107529353  neuroendocrine secretory protein 55-like [KO:K04632]
107528232  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:]
107534062  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:]
107535777  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:]
107544336  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
107543188  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:]
107539056  ARHGDIA; rho GDP-dissociation inhibitor 1 [KO:K12462]
107525352  ARHGDIB; rho GDP-dissociation inhibitor 2 [KO:K12462]
107539648  ARHGDIG; rho GDP-dissociation inhibitor 3 [KO:K12462]
107524712  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
107525737  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
107543873  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
107530327  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
107544136  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
107544933  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
107544390  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
107528114  aquaporin-2-like [KO:K09865]
107533797  RAB11A; ras-related protein Rab-11A [KO:K07904]
107529897  RAB11B; ras-related protein Rab-11B [KO:K07905]
107536492  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
107532412  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
107541728  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
107530249  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
107526387  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
107537214  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
107530351  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
107526847  dynein light chain 1, cytoplasmic-like [KO:K10418]
107535267  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
107528465  dynein light chain 1, cytoplasmic-like [KO:K10418]
107528499  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
107529260  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
107546191  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
107537867  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
107544742  DCTN5; dynactin subunit 5 [KO:K10427]
107534096  DCTN6; dynactin subunit 6 [KO:K10428]
107544497  VAMP2; vesicle-associated membrane protein 2 [KO:K13504]
107530228  NSF; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:]
107540811  STX4; syntaxin-4 [KO:K13502]
107526355  RAB5A; ras-related protein Rab-5A [KO:K07887]
107538222  RAB5B; ras-related protein Rab-5B [KO:K07888]
107544208  RAB5C; ras-related protein Rab-5C [KO:K07889]
107524200  AQP4; aquaporin-4 [KO:K09866]
107544891  AQP3; aquaporin-3 [KO:K09876]
C00001  H2O
C00575  3',5'-Cyclic AMP
Boone M, Deen PM
Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.
Pflugers Arch 456:1005-24 (2008)
Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T
Localization and trafficking of aquaporin 2 in the kidney.
Histochem Cell Biol 130:197-209 (2008)
Nielsen S, Kwon TH, Christensen BM, Promeneur D, Frokiaer J, Marples D
Physiology and pathophysiology of renal aquaporins.
J Am Soc Nephrol 10:647-63 (1999)
Marples D, Frokiaer J, Nielsen S
Long-term regulation of aquaporins in the kidney.
Am J Physiol 276:F331-9 (1999)
Ward DT, Hammond TG, Harris HW
Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.
Annu Rev Physiol 61:683-97 (1999)
Fenton RA, Moeller HB
Recent discoveries in vasopressin-regulated aquaporin-2 trafficking.
Prog Brain Res 170:571-9 (2008)
Nielsen S, Frokiaer J, Marples D, Kwon TH, Agre P, Knepper MA
Aquaporins in the kidney: from molecules to medicine.
Physiol Rev 82:205-44 (2002)
Deen PM, van Balkom BW, Kamsteeg EJ
Routing of the aquaporin-2 water channel in health and disease.
Eur J Cell Biol 79:523-30 (2000)
Bonilla-Felix M
Development of water transport in the collecting duct.
Am J Physiol Renal Physiol 287:F1093-101 (2004)
Uawithya P, Pisitkun T, Ruttenberg BE, Knepper MA
Transcriptional profiling of native inner medullary collecting duct cells from rat kidney.
Physiol Genomics 32:229-53 (2008)
Nguyen MK, Nielsen S, Kurtz I
Molecular pathogenesis of nephrogenic diabetes insipidus.
Clin Exp Nephrol 7:9-17 (2003)
mna04144  Endocytosis
mna04530  Tight junction
KO pathway

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