KEGG   PATHWAY: mpah04392
Entry
mpah04392                   Pathway                                

Name
Hippo signaling pathway - multiple species - Mus pahari (shrew mouse)
Description
Hippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evolution, with related forms described in animals and fungi. In Drosophila and mammals, Hippo/MST co-operate with Mats/Mob1 and Salvador/WW45 to activate Warts/LATS, which negatively regulates Yorkie/YAP. Yorkie/YAP interact with Scalloped/TEAD to promote gene transcriptions and control organ size through the balance between cell proliferation and apoptosis. In C. elegans, WTS-1 YAP-1 EGL-44 axis is conserved and regulates thermotolerance and healthy lifespan. In S. cerevisiae, the LATS-related Dbf2 or Dbf20 kinase in complex with Mob1 controls mitotic exit and cytokinesis, and the Hippo/MST family of kinases, STE-20, modulates Tec1, the putative yeast TEAD ortholog.
Class
Environmental Information Processing; Signal transduction
Pathway map
mpah04392  Hippo signaling pathway - multiple species
mpah04392

Other DBs
GO: 0035329
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110326393  Dchs1; protocadherin-16 [KO:K16507]
110320813  Dchs2; protocadherin-23 [KO:K16507]
110319952  Fat4; protocadherin Fat 4 isoform X1 [KO:K16669]
110334729  casein kinase I [KO:K08960] [EC:2.7.11.1]
110330198  Nf2; merlin isoform X1 [KO:K16684]
110331237  Wwc1; protein KIBRA isoform X1 [KO:K16685]
110324431  Frmd6; FERM domain-containing protein 6 isoform X1 [KO:K16822]
110327714  Rassf1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
110330820  Rassf6; ras association domain-containing protein 6 isoform X1 [KO:K09854]
110334720  Stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
110324307  Sav1; protein salvador homolog 1 [KO:K16686]
110325918  Lats2; serine/threonine-protein kinase LATS2 isoform X1 [KO:K08791] [EC:2.7.11.1]
110338161  Lats1; serine/threonine-protein kinase LATS1 [KO:K08791] [EC:2.7.11.1]
110315942  Mob1a; MOB kinase activator 1A isoform X1 [KO:K06685]
110330335  Mob1b; MOB kinase activator 1B [KO:K06685]
110327504  Limd1; LIM domain-containing protein 1 [KO:K16682]
110325431  Ajuba; LIM domain-containing protein ajuba [KO:K16682]
110328413  Wtip; Wilms tumor protein 1-interacting protein [KO:K16682]
110327706  Yap1; transcriptional coactivator YAP1 isoform X1 [KO:K16687]
110320091  Wwtr1; WW domain-containing transcription regulator protein 1 isoform X1 [KO:K16820]
110315959  Tead4; transcriptional enhancer factor TEF-3 isoform X1 [KO:K09448]
110322324  Tead1; transcriptional enhancer factor TEF-1 isoform X1 [KO:K09448]
110319868  Tead2; transcriptional enhancer factor TEF-4 isoform X1 [KO:K09448]
110337942  Tead3; transcriptional enhancer factor TEF-5 [KO:K09448]
110318972  Rassf2; ras association domain-containing protein 2 [KO:K09851]
110316047  Rassf4; ras association domain-containing protein 4 [KO:K09851]
110319929  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
Reference
  Authors
Hilman D, Gat U
  Title
The evolutionary history of YAP and the hippo/YAP pathway.
  Journal
Mol Biol Evol 28:2403-17 (2011)
DOI:10.1093/molbev/msr065
Reference
  Authors
Varelas X
  Title
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.
  Journal
Development 141:1614-26 (2014)
DOI:10.1242/dev.102376
Reference
  Authors
Zhao B, Tumaneng K, Guan KL
  Title
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
  Journal
Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303
Reference
  Authors
Halder G, Johnson RL
  Title
Hippo signaling: growth control and beyond.
  Journal
Development 138:9-22 (2011)
DOI:10.1242/dev.045500
Reference
  Authors
Pan D
  Title
The hippo signaling pathway in development and cancer.
  Journal
Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011
Reference
  Authors
Zhao B, Li L, Lei Q, Guan KL
  Title
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
  Journal
Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210
Reference
  Authors
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
  Title
Hippo and rassf1a Pathways: A Growing Affair.
  Journal
Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628
Reference
  Authors
Gogl G, Schneider KD, Yeh BJ, Alam N, Nguyen Ba AN, Moses AM, Hetenyi C, Remenyi A, Weiss EL
  Title
The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism.
  Journal
PLoS Biol 13:e1002146 (2015)
DOI:10.1371/journal.pbio.1002146
Reference
  Authors
Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, Ikeda M, Nakagawa K, Hata Y
  Title
Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.
  Journal
Exp Cell Res 319:931-45 (2013)
DOI:10.1016/j.yexcr.2013.01.020
Reference
  Authors
Yang Z, Hata Y
  Title
What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans?
  Journal
J Biochem 154:207-9 (2013)
DOI:10.1093/jb/mvt060
Reference
  Authors
Hotz M, Barral Y
  Title
The Mitotic Exit Network: new turns on old pathways.
  Journal
Trends Cell Biol 24:145-52 (2014)
DOI:10.1016/j.tcb.2013.09.010
Reference
  Authors
Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A
  Title
Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.
  Journal
Science 340:871-5 (2013)
DOI:10.1126/science.1235822
Reference
  Authors
Hergovich A, Hemmings BA
  Title
Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.
  Journal
Semin Cell Dev Biol 23:794-802 (2012)
DOI:10.1016/j.semcdb.2012.04.001
Reference
  Authors
Wang Y, Abu Irqeba A, Ayalew M, Suntay K
  Title
Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast.
  Journal
PLoS One 4:e7456 (2009)
DOI:10.1371/journal.pone.0007456
Related
pathway
mpah04390  Hippo signaling pathway
KO pathway
ko04392   
LinkDB

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