Mycobacterium tuberculosis EAI5: M943_02660
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Entry
M943_02660 CDS
T02749
Name
(GenBank) uroporphyrin-III C-methyltransferase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mtx
Mycobacterium tuberculosis EAI5
Pathway
mtx00860
Porphyrin metabolism
mtx01100
Metabolic pathways
mtx01110
Biosynthesis of secondary metabolites
mtx01120
Microbial metabolism in diverse environments
mtx01240
Biosynthesis of cofactors
Module
mtx_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mtx_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mtx00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
M943_02660
Enzymes [BR:
mtx01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
M943_02660
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
M943_02660
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Paralog
Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
AGQ34050
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Position
602818..604524
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AA seq
568 aa
AA seq
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MTIMTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDL
PPVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEAR
SGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVA
DVRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQR
SVETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWT
VLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTS
TNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDD
FPPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIK
TGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGP
LVDALAEHAARLRAEGALPPPRKKSRRR
NT seq
1707 nt
NT seq
+upstream
nt +downstream
nt
gtgacaatcatgacgcgagggcgtaagccgagaccgggccgcatcgttttcgtgggctcc
ggtccgggcgaccccggcttgcttacgacacgggctgccgcggtgctggccaacgccgcg
ctggtgttcaccgatcccgacgtaccggagccggtggtggcgctgatcggcacggatctg
ccccccgtgtccggcccggcgcccgccgagccggttgccgggaacggcgatgcggccggc
ggaggaagtgcgcaggaacacggccgggccgcgtccgcggtagtctccggtggtcctgac
atccgcccggcgctgggcgatcccgccgatgtggccaagacgctgaccgccgaggcccgt
tcgggtgtcgacgtggtgcggctggtggcgggcgatccgctcacggtggatgcggtaatc
agcgaggtgaacgccgtcgcacgcacccacctgcacatcgaaatcgtgcccggcctggcc
gccagcagcgcggtcccgacctatgccgggttgccgctgggttcgtcgcacaccgtcgcc
gacgtgcgtatcgaccccgaaaacaccgactgggacgcgctggctgccgcacccgggccg
ctgatcctgcaggccaccgcatcgcatctagccgaatcggcccgcagcctgatcgatcac
cagctggccgagtccactccgtgcgtggtgaccgcacacggcaccacctgtcagcagcgt
tcggtcgagaccacacttcagggattgaccgacccggccgtcctgggcgctaccgacccc
gcgtgctccgcaaacgggagggactcccaggccggaccgctgatagtgaccatcggcaag
acggtgaccagtcgggcaaagctgaactggtgggagagccgcgccctctacggctggacg
gtgttggtgccgcgcaccaaggaccaggccggcgagatgagcgagcggctcacgtcgtac
ggcgcgctgccggtggaggtgccgaccatcgccgtcgagccgccgcgcagccccgcgcag
atggagcgcgccgtcaagggcctggtcgatggccgattccagtggatcgtgttcacctcc
accaacgcggtgcgtgcggtgtgggagaagttcggcgagttcggtctggatgcccgcgcg
ttctccggggtgaagatcgcctgtgtcggcgagtcgacggccgaccgggtgcgcgccttc
ggaatcagtcccgagctggtgccctccggggagcagtcctcgcttggcttgctagacgac
ttcccgccctacgacagcgttttcgacccggtgaaccgggttttgctgccgcgcgccgac
atcgccaccgaaacgctggccgagggactgcgagagcgtggctgggagatcgaggacgtc
accgcctaccggaccgtgcgggccgcgccgccgccggccactacccgggaaatgatcaag
acgggcgggtttgacgcggtatgtttcacctccagctcgacggtgcgaaacctggtcggc
atcgccggcaagccgcacgcgcggacgatcatcgcctgcatagggccaaagaccgccgag
accgcagccgagttcggcttgcgggtcgatgtccagccggacaccgccgccatcggcccg
ctggtcgatgcgctggccgagcatgccgcccggttgcgcgctgagggtgcgctgcccccg
ccgcgcaagaagagccgcaggcgctag
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