Myotis davidii (David's myotis): 102756475 Help Entry 102756475         CDS       T02992                                  Symbol PLCG1 Name (RefSeq) phospholipase C gamma 1   KO K01116   phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11] Organism myd  Myotis davidii (David's myotis) Pathway myd00562   Inositol phosphate metabolism myd01100   Metabolic pathways myd01521   EGFR tyrosine kinase inhibitor resistance myd04012   ErbB signaling pathway myd04014   Ras signaling pathway myd04015   Rap1 signaling pathway myd04020   Calcium signaling pathway myd04062   Chemokine signaling pathway myd04064   NF-kappa B signaling pathway myd04066   HIF-1 signaling pathway myd04070   Phosphatidylinositol signaling system myd04072   Phospholipase D signaling pathway myd04360   Axon guidance myd04370   VEGF signaling pathway myd04613   Neutrophil extracellular trap formation myd04650   Natural killer cell mediated cytotoxicity myd04658   Th1 and Th2 cell differentiation myd04659   Th17 cell differentiation myd04660   T cell receptor signaling pathway myd04664   Fc epsilon RI signaling pathway myd04666   Fc gamma R-mediated phagocytosis myd04670   Leukocyte transendothelial migration myd04722   Neurotrophin signaling pathway myd04750   Inflammatory mediator regulation of TRP channels myd04919   Thyroid hormone signaling pathway myd04933   AGE-RAGE signaling pathway in diabetic complications myd04935   Growth hormone synthesis, secretion and action myd05012   Parkinson disease myd05022   Pathways of neurodegeneration - multiple diseases myd05135   Yersinia infection myd05167   Kaposi sarcoma-associated herpesvirus infection myd05170   Human immunodeficiency virus 1 infection myd05171   Coronavirus disease - COVID-19 myd05200   Pathways in cancer myd05205   Proteoglycans in cancer myd05206   MicroRNAs in cancer myd05214   Glioma myd05223   Non-small cell lung cancer myd05225   Hepatocellular carcinoma myd05231   Choline metabolism in cancer myd05235   PD-L1 expression and PD-1 checkpoint pathway in cancer myd05417   Lipid and atherosclerosis Module myd_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:myd00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     102756475 (PLCG1)  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     102756475 (PLCG1)    04014 Ras signaling pathway     102756475 (PLCG1)    04015 Rap1 signaling pathway     102756475 (PLCG1)    04370 VEGF signaling pathway     102756475 (PLCG1)    04064 NF-kappa B signaling pathway     102756475 (PLCG1)    04066 HIF-1 signaling pathway     102756475 (PLCG1)    04020 Calcium signaling pathway     102756475 (PLCG1)    04070 Phosphatidylinositol signaling system     102756475 (PLCG1)    04072 Phospholipase D signaling pathway     102756475 (PLCG1)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     102756475 (PLCG1)    04650 Natural killer cell mediated cytotoxicity     102756475 (PLCG1)    04660 T cell receptor signaling pathway     102756475 (PLCG1)    04658 Th1 and Th2 cell differentiation     102756475 (PLCG1)    04659 Th17 cell differentiation     102756475 (PLCG1)    04664 Fc epsilon RI signaling pathway     102756475 (PLCG1)    04666 Fc gamma R-mediated phagocytosis     102756475 (PLCG1)    04670 Leukocyte transendothelial migration     102756475 (PLCG1)    04062 Chemokine signaling pathway     102756475 (PLCG1)   09152 Endocrine system    04935 Growth hormone synthesis, secretion and action     102756475 (PLCG1)    04919 Thyroid hormone signaling pathway     102756475 (PLCG1)   09156 Nervous system    04722 Neurotrophin signaling pathway     102756475 (PLCG1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     102756475 (PLCG1)   09158 Development and regeneration    04360 Axon guidance     102756475 (PLCG1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102756475 (PLCG1)    05206 MicroRNAs in cancer     102756475 (PLCG1)    05205 Proteoglycans in cancer     102756475 (PLCG1)    05231 Choline metabolism in cancer     102756475 (PLCG1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102756475 (PLCG1)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     102756475 (PLCG1)    05214 Glioma     102756475 (PLCG1)    05223 Non-small cell lung cancer     102756475 (PLCG1)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102756475 (PLCG1)    05171 Coronavirus disease - COVID-19     102756475 (PLCG1)    05167 Kaposi sarcoma-associated herpesvirus infection     102756475 (PLCG1)   09171 Infectious disease: bacterial    05135 Yersinia infection     102756475 (PLCG1)   09164 Neurodegenerative disease    05012 Parkinson disease     102756475 (PLCG1)    05022 Pathways of neurodegeneration - multiple diseases     102756475 (PLCG1)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102756475 (PLCG1)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102756475 (PLCG1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102756475 (PLCG1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:myd04131]     102756475 (PLCG1) Enzymes [BR:myd01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      102756475 (PLCG1) Membrane trafficking [BR:myd04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     102756475 (PLCG1)  Endocytosis   Macropinocytosis    Phospholipase C     102756475 (PLCG1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI-PLC-X SH2 PI-PLC-Y C2 SH3_1 PH SH3_9 SH3_2 GDPD PH_9 EF-hand_6 EF-hand_7 Motif Other DBs NCBI-GeneID:  102756475 NCBI-ProteinID:  XP_015419399 LinkDB All DBs Position Un AA seq 1178 aa AA seqDB search MEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRI SAKDLKNMLSQVNYRVPNMRSLRERLTDLELRSSDITYGQFAQVYRSLMYSDQKTMDLPF LEACAPRAGERPELCRMSLPEFQQFLLEYQAELWAVDRLQVQEFMLDFLRDPLREIEEPY FSLDEFVTFLFSKENSVWNSQLDVVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEA YARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS IEDHCSIAQQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAY EEVPSSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDE EEPKEASGSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFV GDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMR LSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKI KHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYG ALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQRDDELTFTKSAIIQNVEKQDGGWWRGD YGGKKQLWFPSNYVEEMVSPAVLEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNN RPFVFSISMASVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALE LSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIY PKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGGHCGYVLQPSTMRDE AFDPFDKSSLRGLEPRAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDNNKQKTEFVV DNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPL KNNYSEDLELASLLVKVDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFEAR YQQPFEDFRISQEHLPDNFDSRERRAPRRTRVNGDNRL NT seq 3537 nt NT seq  +upstreamnt  +downstreamnt atggaattccgcctgaagaccctgagtttgcaagctacatctgaggatgaagtgaacatg tggatcaagggcttgacttggctgatggaggacacattgcaggcagccacacccctgcag attgagaggtggctgcggaagcagttctactcggtggatcggaatcgtgaggatcgtata tcagccaaggacctgaagaatatgctgtcccaggtcaactaccgggtccccaacatgcgc tccctccgagagcgtctgacggacctggagctgcgcagcagcgatatcacctatgggcag tttgctcaggtgtaccgcagcctcatgtacagcgaccagaagacgatggacctccccttc ttggaagcctgcgccccaagggcaggggagcggccggagctctgccgaatgtcccttccg gagttccagcagttcctccttgagtaccaggcggagctgtgggctgtcgaccgactccag gtgcaggagttcatgctcgacttcctccgagaccccttgagagagattgaggagccatac ttctccctggatgagtttgtcaccttcctgttctctaaggagaacagtgtgtggaactcg cagctggatgtggtgtgcccggacaccatgaacaaccctctctctcactattggatctcc tcctcgcacaacacgtacctgaccggggaccagttctccagcgagtcctccctggaagcc tatgctcgctgcctgcgcatgggctgccgctgtattgagttggactgctgggacggccca gacgggatgccagtcatttaccatggacacacccttacaaccaagatcaagttctcagac gtcctgcacaccatcaaggagcatgccttcgtggcctcagagtacccggtcatcctgtcc atcgaggaccactgcagcattgctcagcagaggaacatggcccagtacttcaagaaggtg ctcggggacacactcctcaccaagcccgtggacattgctgccgatgggctcccttccccc aaccagctcaagaggaagatccttatcaagcacaagaagctggctgagggcagtgcctat gaggaggtgccttcgtctgtgatgtactctgagaacgacatcagcaactccatcaagaat gggatcctctacctggaagaccccgtgaaccatgagtggtatccccactactttgttctg accagcagcaagatctactactctgaggagaccagcagtgaccagggcaatgaggatgag gaagagcccaaggaggccagtggcagcaccgagctgcactccaatgagaagtggttccat gggaagcttggggcaggacgggacgggaggcacattgccgagcgcctgctgactgagtac tgcattgagaccggggcccctgatggctccttcctagtgcgcgagagcgagaccttcgtt ggcgactacaccctctctttctggcggaacgggaaggtccaacactgccggatccactcc cggcaggatgctgggacccccaagttcttcttgacagacaaccttgtatttgactcactc tatgacctcatcacgcactaccagcaggtgcccctgcgctgcaatgaatttgagatgcgc ctctcggagcctgtcccccagaccaatgcccacgaaagcaaagaatggtaccacgcaagc ctgaccagagcgcaggctgagcacatgctgatgcgcgtcccccgtgatggggccttcctg gtgcggaaacggaatgagcccaactcctacgccatctccttccgggctgaaggcaagatc aagcattgccgcgtccagcaggagggccagacagtgatgctgggcaactcggagtttgac agccttgtcgacctcatcagttactatgagaagcatccactgtatcgaaagatgaagctg cgctatcccatcaatgaggaggcactggagaagataggcacagctgagcctgactatggg gccttgtatgagggacgcaaccctggcttttatgtggaggcaaaccctatgccgactttt aagtgtgcagtcaaagccctctttgactacaaggcgcagagagacgacgagctgactttc accaagagcgccatcatccagaatgtggagaagcaggacggaggctggtggcgaggagac tatggtgggaagaagcaactctggttcccgtcaaactacgtggaggagatggtcagccca gcagtcctggagcctgagagggagcacttggacgagaacagccccctgggggacttgctg cggggggtcttggatgttccagcttgtcagattgccatccgtcctgagggcaagaacaat cggccattcgtcttctccatcagtatggcatcggtggcgcaatggtccctggatgttgct gccgactcacaggaggagctgcaggactgggtgaaaaagatccgtgaagtggcccagacc gcagatgccaggctcactgaggggaagatgatggagcggaggaagaagatcgcccttgaa ctctccgagcttgtcgtctactgccggcctgttcccttcgatgaagagaagattggcaca gaacgtgcctgctaccgggacatgtcgtccttcccggaaaccaaggcggagaagtatgtg aacaaggccaaaggcaagaagttcctgcagtacaaccggctgcagctctcccgcatctac cccaagggccagcggctagactcctccaattatgaccccttgcccatgtggatctgtggc agtcagctggtggccctcaacttccagaccccagacaagcccatgcagatgaaccaggcc ctcttcatgaccggcgggcactgcggctatgtgctgcagcccagcaccatgcgggacgag gccttcgacccctttgacaagagcagcctccgagggctggagccacgcgccatctgcatc gaggtgctgggcgcccggcatctaccaaagaatggccgcggcattgtgtgtccctttgtg gagattgaggttgctggagctgagtatgacaacaacaagcagaagacagagtttgtggtg gacaatggcctcaaccccgtgtggccggccaagcccttccacttccaaatcagtaaccct gaattcgctttcctgcgctttgtggtgtatgaggaagacatgtttagtgaccagaacttc ctggctcaggctactttcccagtgaaaggcctgaagacaggatacagagcagtgcctttg aagaacaactacagtgaggacctggagttggcttccctactggtcaaggtcgacattttc cctgccaaggagaacggtgacctcagtcccttcagtggcacgtccctgcgggagcggggc tctgatgcctcgggccaactgttccatggccgggcccgcgaaggctcctttgaagcgcgc taccagcagccatttgaagactttcgcatctcccaggagcatctcccagacaattttgac agccgggagagaagggccccacgaaggactcgggtcaacggagacaatcgcctctag

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