KEGG   NETWORK: N00004Help
Entry
N00004                      Network                                

Name
Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
Definition
FLT3* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
(2322v2,2322v1) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06275 Acute myeloid leukemia
Type
Variant
Pathway
hsa05221  Acute myeloid leukemia
Disease
H00003  Acute myeloid leukemia
Gene
2322  FLT3; fms related tyrosine kinase 3
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Variant
2322v2  FLT3 internal tandem duplication (ITD)
2322v1  FLT3 kinase domain mutation
Reference
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
  Authors
Doepfner KT, Boller D, Arcaro A
  Title
Targeting receptor tyrosine kinase signaling in acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 63:215-30 (2007)
DOI:10.1016/j.critrevonc.2007.05.005
Reference
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
  Authors
Stirewalt DL, Meshinchi S, Radich JP
  Title
Molecular targets in acute myelogenous leukemia.
  Journal
Blood Rev 17:15-23 (2003)
DOI:10.1016/S0268-960X(02)00057-7
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