KEGG   NETWORK: N00007Help
Entry
N00007                      Network                                

Name
EML4-ALK fusion kinase to RAS-ERK signaling pathway
Definition
EML4-ALK -> RAS -> RAF -> MEK -> ERK -> CCND1
  Expanded
(238v1,238v2) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595
Class
nt06210 ERK signaling
nt06266 Non-small cell lung cancer
Type
Variant
Pathway
hsa05223  Non-small cell lung cancer
Disease
H00014  Non-small cell lung cancer
Gene
238  ALK; ALK receptor tyrosine kinase
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
595  CCND1; cyclin D1
Variant
238v1  EML4-ALK fusion
238v2  First generation TKI-resistant ALK1 mutation
Reference
  Authors
Reungwetwattana T, Weroha SJ, Molina JR
  Title
Oncogenic pathways, molecularly targeted therapies, and highlighted clinical trials in non-small-cell lung cancer (NSCLC).
  Journal
Clin Lung Cancer 13:252-66 (2012)
DOI:10.1016/j.cllc.2011.09.004
Reference
  Authors
Roskoski R Jr
  Title
Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition.
  Journal
Pharmacol Res 68:68-94 (2013)
DOI:10.1016/j.phrs.2012.11.007
Reference
  Authors
Janne PA, Gray N, Settleman J
  Title
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors.
  Journal
Nat Rev Drug Discov 8:709-23 (2009)
DOI:10.1038/nrd2871
Reference
  Authors
Solomon B, Wilner KD, Shaw AT
  Title
Current status of targeted therapy for anaplastic lymphoma kinase-rearranged non-small cell lung cancer.
  Journal
Clin Pharmacol Ther 95:15-23 (2014)
DOI:10.1038/clpt.2013.200
LinkDB All DBs

DBGET integrated database retrieval system