KEGG   NETWORK: N00008
Entry
N00008                      Network                                

Name
RET fusion kinase to RAS-ERK signaling pathway
Definition
RET* -> RAS -> RAF -> MEK -> ERK
  Expanded
5979v1 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06266 Non-small cell lung cancer
nt06274 Thyroid cancer
Type
Variant
Pathway
hsa05216  Thyroid cancer
hsa05223  Non-small cell lung cancer
Disease
H00032  Thyroid cancer
H00014  Non-small cell lung cancer
Gene
5979  RET; ret proto-oncogene
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Variant
5979v1 (RET*)  RET fusion
Reference
  Authors
Tirro E, Martorana F, Romano C, Vitale SR, Motta G, Di Gregorio S, Massimino M, Pennisi MS, Stella S, Puma A, Giani F, Russo M, Manzella L, Vigneri P
  Title
Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice.
  Journal
Genes (Basel) 10:genes10090709 (2019)
DOI:10.3390/genes10090709
Reference
  Authors
Ferrara R, Auger N, Auclin E, Besse B
  Title
Clinical and Translational Implications of RET Rearrangements in Non-Small Cell Lung Cancer.
  Journal
J Thorac Oncol 13:27-45 (2018)
DOI:10.1016/j.jtho.2017.10.021
Reference
  Authors
Santoro M, Moccia M, Federico G, Carlomagno F
  Title
RET Gene Fusions in Malignancies of the Thyroid and Other Tissues.
  Journal
Genes (Basel) 11:genes11040424 (2020)
DOI:10.3390/genes11040424
Reference
  Authors
Al-Jundi M, Thakur S, Gubbi S, Klubo-Gwiezdzinska J
  Title
Novel Targeted Therapies for Metastatic Thyroid Cancer-A Comprehensive Review.
  Journal
Cancers (Basel) 12:cancers12082104 (2020)
DOI:10.3390/cancers12082104
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