KEGG   NETWORK: N00012Help
Entry
N00012                      Network                                

Name
Mutation-activated KRAS/NRAS to ERK signaling pathway
Definition
(KRAS*,NRAS*) -> RAF -> MEK -> ERK -> CCND1
  Expanded
(3845v1,4893v1) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595
Class
nt06210 ERK signaling
nt06260 Colorectal cancer
nt06261 Gastric cancer
nt06262 Pancreatic cancer
nt06266 Non-small cell lung cancer
nt06268 Melanoma
nt06271 Endometrial cancer
nt06274 Thyroid cancer
nt06275 Acute myeloid leukemia
Type
Variant
Pathway
hsa05210  Colorectal cancer
hsa05212  Pancreatic cancer
hsa05226  Gastric cancer
hsa05216  Thyroid cancer
hsa05221  Acute myeloid leukemia
hsa05213  Endometrial cancer
hsa05223  Non-small cell lung cancer
hsa05218  Melanoma
Disease
H00020  Colorectal cancer
H00019  Pancreatic cancer
H00018  Gastric cancer
H00032  Thyroid cancer
H00003  Acute myeloid leukemia
H00026  Endometrial cancer
H00014  Non-small cell lung cancer
H00038  Melanoma
Gene
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
595  CCND1; cyclin D1
Variant
3845v1  KRAS mutation
4893v1  NRAS mutation
Reference
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
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