KEGG   NETWORK: N00013Help
Entry
N00013                      Network                                

Name
Mutation-activated BRAF to ERK signaling pathway
Definition
BRAF* -> MEK -> ERK
  Expanded
673v1 -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06268 Melanoma
nt06274 Thyroid cancer
Type
Variant
Pathway
hsa05216 Thyroid cancer   
hsa05218 Melanoma   
Disease
H00032  Thyroid cancer
H00038  Melanoma
Gene
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Variant
673v1  BRAF mutation
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
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