KEGG   NETWORK: N00015Help
Entry
N00015                      Network                                

Name
PDGF-PDGFR-RAS-ERK signaling pathway
Definition
PDGF -> PDGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
(5154,5155) -> (5156,5159) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06273 Glioma
nt06110 MAPK signaling (virus)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
Gene
5154  PDGFA; platelet derived growth factor subunit A
5155  PDGFB; platelet derived growth factor subunit B
5156  PDGFRA; platelet derived growth factor receptor alpha
5159  PDGFRB; platelet derived growth factor receptor beta
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
  Authors
Molina JR, Adjei AA
  Title
The Ras/Raf/MAPK pathway.
  Journal
J Thorac Oncol 1:7-9 (2006)
DOI:10.1016/S1556-0864(15)31506-9
Reference
  Authors
Dibb NJ, Dilworth SM, Mol CD
  Title
Switching on kinases: oncogenic activation of BRAF and the PDGFR family.
  Journal
Nat Rev Cancer 4:718-27 (2004)
DOI:10.1038/nrc1434
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