KEGG   NETWORK: N00027Help
Entry
N00027                      Network                                

Name
Amplified EGFR to PLCG-CAMK signaling pathway
Definition
EGFR* -> PLCG -> IP3 -> Ca2+ -> CALM -- CAMK
  Expanded
1956v1 -> (5335,5336) -> C01245 -> C00076 -> (801,805,808) -- (8536,57118,57172,815,816,817,818,814)
Class
nt06220 Calcium signaling
nt06273 Glioma
Type
Variant
Pathway
hsa05214  Glioma
Disease
H00042  Glioma
Gene
1956  EGFR; epidermal growth factor receptor
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
8536  CAMK1; calcium/calmodulin dependent protein kinase I
57118  CAMK1D; calcium/calmodulin dependent protein kinase ID
57172  CAMK1G; calcium/calmodulin dependent protein kinase IG
815  CAMK2A; calcium/calmodulin dependent protein kinase II alpha
816  CAMK2B; calcium/calmodulin dependent protein kinase II beta
817  CAMK2D; calcium/calmodulin dependent protein kinase II delta
818  CAMK2G; calcium/calmodulin dependent protein kinase II gamma
814  CAMK4; calcium/calmodulin dependent protein kinase IV
Variant
1956v1  EGFR amplification
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
  Authors
Khoshyomn S, Penar PL, Rossi J, Wells A, Abramson DL, Bhushan A
  Title
Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates.
  Journal
Neurosurgery 44:568-77 (1999)
DOI:10.1097/00006123-199903000-00073
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