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Entry
N00030                      Network                                

Name
EGF-EGFR-RAS-PI3K signaling pathway
Definition
EGF -> EGFR -> GRB2 -> SOS -> RAS -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
1950 -> 1956 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06214 PI3K signaling
nt06260 Colorectal cancer
nt06268 Melanoma
nt06114 PI3K signaling (virus)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04014  Ras signaling pathway
hsa04151  PI3K-Akt signaling pathway
Gene
1950  EGF; epidermal growth factor
1956  EGFR; epidermal growth factor receptor
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Cantley LC
  Title
The phosphoinositide 3-kinase pathway.
  Journal
Science 296:1655-7 (2002)
DOI:10.1126/science.296.5573.1655
Reference
  Authors
Bertotti A, Sassi F
  Title
Molecular Pathways: Sensitivity and Resistance to Anti-EGFR Antibodies.
  Journal
Clin Cancer Res 21:3377-83 (2015)
DOI:10.1158/1078-0432.CCR-14-0848
Reference
  Authors
Makker A, Goel MM, Mahdi AA
  Title
PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update.
  Journal
J Mol Endocrinol 53:R103-18 (2014)
DOI:10.1530/JME-14-0220
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
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