KEGG   NETWORK: N00035Help
Entry
N00035                      Network                                

Name
Amplified EGFR to PI3K signaling pathway
Definition
EGFR* -> PI3K -> PIP3 -> AKT -> MTOR
  Expanded
1956v1 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475
Class
nt06214 PI3K signaling
nt06273 Glioma
Type
Variant
Pathway
hsa05214  Glioma
Disease
H00042  Glioma
Gene
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
Variant
1956v1  EGFR amplification
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Li X, Wu C, Chen N, Gu H, Yen A, Cao L, Wang E, Wang L
  Title
PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma.
  Journal
Oncotarget 7:33440-50 (2016)
DOI:10.18632/oncotarget.7961
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