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Entry
N00038                      Network                                

Name
Amplified FGFR to PI3K signaling pathway
Definition
FGFR* -> PI3K -> PIP3 -> AKT -> MTOR
  Expanded
(2260v1,2263v1) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475
Class
nt06214 PI3K signaling
nt06261 Gastric cancer
nt06270 Breast cancer
Type
Variant
Pathway
hsa05224  Breast cancer
hsa05226  Gastric cancer
Disease
H00031  Breast cancer
H00018  Gastric cancer
Gene
2260  FGFR1; fibroblast growth factor receptor 1
2263  FGFR2; fibroblast growth factor receptor 2
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
Variant
2260v1  FGFR1 amplification
2263v1  FGFR2 amplification
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
  Title
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
  Journal
Biomed Rep 2:41-52 (2014)
DOI:10.3892/br.2013.187
Reference
  Authors
Turner N, Pearson A, Sharpe R, Lambros M, Geyer F, Lopez-Garcia MA, Natrajan R, Marchio C, Iorns E, Mackay A, Gillett C, Grigoriadis A, Tutt A, Reis-Filho JS, Ashworth A
  Title
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer.
  Journal
Cancer Res 70:2085-94 (2010)
DOI:10.1158/0008-5472.CAN-09-3746
Reference
  Authors
Katoh M, Nakagama H
  Title
FGF receptors: cancer biology and therapeutics.
  Journal
Med Res Rev 34:280-300 (2014)
DOI:10.1002/med.21288
Reference
  Authors
Katoh M
  Title
FGFR2 abnormalities underlie a spectrum of bone, skin, and cancer pathologies.
  Journal
J Invest Dermatol 129:1861-7 (2009)
DOI:10.1038/jid.2009.97
Reference
  Authors
Katoh M
  Title
Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics.
  Journal
Expert Rev Anticancer Ther 10:1375-9 (2010)
DOI:10.1586/era.10.128
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