KEGG   NETWORK: N00040Help
Entry
N00040                      Network                                

Name
Amplified PDGFR to PI3K signaling pathway
Definition
PDGFR* -> PI3K -> PIP3 -> AKT -> MTOR
  Expanded
5156v1 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475
Class
nt06214 PI3K signaling
nt06273 Glioma
Type
Variant
Pathway
hsa05214  Glioma
Disease
H00042  Glioma
Gene
5156  PDGFRA; platelet derived growth factor receptor alpha
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
Variant
5156v1  PDGFRA amplification
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Westermark B
  Title
Platelet-derived growth factor in glioblastoma-driver or biomarker?
  Journal
Ups J Med Sci 119:298-305 (2014)
DOI:10.3109/03009734.2014.970304
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
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