KEGG   NETWORK: N00041Help
Entry
N00041                      Network                                

Name
EGFR-overexpression to RAS-ERK signaling pathway
Definition
EGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
1956v4 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06260 Colorectal cancer
nt06265 Bladder cancer
nt06266 Non-small cell lung cancer
nt06270 Breast cancer
nt06273 Glioma
Type
Variant
Pathway
hsa05210  Colorectal cancer
hsa05214  Glioma
hsa05219  Bladder cancer
hsa05224  Breast cancer
hsa05223  Non-small cell lung cancer
Disease
H00020  Colorectal cancer
H00042  Glioma
H00022  Bladder cancer
H00031  Breast cancer
H00014  Non-small cell lung cancer
Gene
1956  EGFR; epidermal growth factor receptor
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Variant
1956v4  EGFR overexpression
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
  Authors
Alanazi IO, Khan Z
  Title
Understanding EGFR Signaling in Breast Cancer and Breast Cancer Stem Cells: Overexpression and Therapeutic Implications.
  Journal
Asian Pac J Cancer Prev 17:445-53 (2016)
DOI:10.7314/APJCP.2016.17.2.445
Reference
  Authors
Wang D, Xia D, Dubois RN
  Title
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer.
  Journal
Cancers (Basel) 3:3894-908 (2011)
DOI:10.3390/cancers3043894
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