KEGG   NETWORK: N00042Help
Entry
N00042                      Network                                

Name
EGFR-overexpression to PI3K signaling pathway
Definition
EGFR* -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
1956v4 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06214 PI3K signaling
nt06260 Colorectal cancer
nt06270 Breast cancer
nt06273 Glioma
Type
Variant
Pathway
hsa05210  Colorectal cancer
hsa05214  Glioma
hsa05224  Breast cancer
Disease
H00020  Colorectal cancer
H00042  Glioma
H00031  Breast cancer
Gene
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Variant
1956v4  EGFR overexpression
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Wang D, Xia D, Dubois RN
  Title
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer.
  Journal
Cancers (Basel) 3:3894-908 (2011)
DOI:10.3390/cancers3043894
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Li X, Wu C, Chen N, Gu H, Yen A, Cao L, Wang E, Wang L
  Title
PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma.
  Journal
Oncotarget 7:33440-50 (2016)
DOI:10.18632/oncotarget.7961
Reference
  Authors
Alanazi IO, Khan Z
  Title
Understanding EGFR Signaling in Breast Cancer and Breast Cancer Stem Cells: Overexpression and Therapeutic Implications.
  Journal
Asian Pac J Cancer Prev 17:445-53 (2016)
DOI:10.7314/APJCP.2016.17.2.445
Reference
  Authors
Mohamed A, Krajewski K, Cakar B, Ma CX
  Title
Targeted therapy for breast cancer.
  Journal
Am J Pathol 183:1096-112 (2013)
DOI:10.1016/j.ajpath.2013.07.005
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