KEGG   NETWORK: N00048
Entry
N00048                      Network                                

Name
BCR-ABL fusion kinase to PI3K signaling pathway
Definition
BCR-ABL -> (CRKL+CBL+CRK) -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
(25v1,25v2) -> (1399+867+1398) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06214 PI3K signaling
nt06276 Chronic myeloid leukemia
Type
Variant
Pathway
hsa05220  Chronic myeloid leukemia
Disease
H00004  Chronic myeloid leukemia
Gene
25  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
1399  CRKL; CRK proto-oncogene, adaptor protein
867  CBL; Cbl proto-oncogene
1398  CRK; CRK proto-oncogene, adaptor protein
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Variant
25v1 (BCR-ABL)  BCR-ABL1 fusion
25v2 (BCR-ABL)  First generation TKI-resistant ABL1 mutation
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
LinkDB

DBGET integrated database retrieval system