KEGG   NETWORK: N00055Help
Entry
N00055                      Network                                

Name
BCR-ABL fusion kinase to Jak-STAT signaling pathway
Definition
BCR-ABL -> STAT5 => BCL2L1
  Expanded
(25v1,25v2) -> (6776,6777) => 598
Class
nt06219 JAK-STAT signaling
nt06276 Chronic myeloid leukemia
Type
Variant
Pathway
hsa05220  Chronic myeloid leukemia
Disease
H00004  Chronic myeloid leukemia
Gene
25  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
6776  STAT5A; signal transducer and activator of transcription 5A
6777  STAT5B; signal transducer and activator of transcription 5B
598  BCL2L1; BCL2 like 1
Variant
25v1  BCR-ABL1 fusion
25v2  First generation TKI-resistant ABL1 mutation
Reference
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
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