KEGG   NETWORK: N00057Help
Entry
N00057                      Network                                

Name
Mutation-inactivated APC to Wnt signaling pathway
Definition
(GSK3B+AXIN) // APC* // CTNNB1 -> TCF/LEF => (BIRC5,MYC,CCND1)
  Expanded
(2932+(8312,8313)) // 324v1 // 1499 -> (6932,83439,6934,51176) => (332,4609,595)
Class
nt06215 WNT signaling
nt06260 Colorectal cancer
nt06261 Gastric cancer
Type
Variant
Pathway
hsa05210  Colorectal cancer
hsa05226  Gastric cancer
Disease
H00020  Colorectal cancer
H00018  Gastric cancer
Gene
2932  GSK3B; glycogen synthase kinase 3 beta
8312  AXIN1; axin 1
8313  AXIN2; axin 2
324  APC; APC, WNT signaling pathway regulator
1499  CTNNB1; catenin beta 1
6932  TCF7; transcription factor 7
83439  TCF7L1; transcription factor 7 like 1
6934  TCF7L2; transcription factor 7 like 2
51176  LEF1; lymphoid enhancer binding factor 1
332  BIRC5; baculoviral IAP repeat containing 5
4609  MYC; MYC proto-oncogene, bHLH transcription factor
595  CCND1; cyclin D1
Variant
324v1  APC mutation
Reference
  Authors
Duchartre Y, Kim YM, Kahn M
  Title
The Wnt signaling pathway in cancer.
  Journal
Crit Rev Oncol Hematol 99:141-9 (2016)
DOI:10.1016/j.critrevonc.2015.12.005
Reference
  Authors
Takebe N, Harris PJ, Warren RQ, Ivy SP
  Title
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways.
  Journal
Nat Rev Clin Oncol 8:97-106 (2011)
DOI:10.1038/nrclinonc.2010.196
Reference
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
  Authors
Giles RH, van Es JH, Clevers H
  Title
Caught up in a Wnt storm: Wnt signaling in cancer.
  Journal
Biochim Biophys Acta 1653:1-24 (2003)
DOI:10.1016/S0304-419X(03)00005-2
Reference
  Authors
Li X, Wu WK, Xing R, Wong SH, Liu Y, Fang X, Zhang Y, Wang M, Wang J, Li L, Zhou Y, Tang S, Peng S, Qiu K, Chen L, Chen K, Yang H, Zhang W, Chan MT, Lu Y, Sung JJ, Yu J
  Title
Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability.
  Journal
Cancer Res 76:1724-32 (2016)
DOI:10.1158/0008-5472.CAN-15-2443
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