KEGG   NETWORK: N00060
Entry
N00060                      Network                                
Name
LRP6-overexpression to Wnt signaling pathway
Definition
WNT -> (FZD+LRP6*) -> (DVL+FRAT) -| (GSK3B+AXIN+APC) -| CTNNB1 -> TCF/LEF => (MYC,CCND1)
  Expanded
(7471,7472,7482,7473,89780,54361,7474,81029,7475,7476,7477,7478,7479,7483,7484,80326,7480,51384) -> ((8321,2535,7976,8322,7855,8323,8324,8325,8326,11211)+4040v1) -> ((1855,1856,1857)+(10023,23401)) -| (2932+(8312,8313)+324) -| 1499 -> (6932,83439,6934,51176) => (4609,595)
Class
nt06270 Breast cancer
nt06215 WNT signaling (cancer)
Type
Variant
Pathway
hsa05224  Breast cancer
Disease
H00031  Breast cancer
Gene
7471  WNT1; Wnt family member 1
7472  WNT2; Wnt family member 2
7482  WNT2B; Wnt family member 2B
7473  WNT3; Wnt family member 3
89780  WNT3A; Wnt family member 3A
54361  WNT4; Wnt family member 4
7474  WNT5A; Wnt family member 5A
81029  WNT5B; Wnt family member 5B
7475  WNT6; Wnt family member 6
7476  WNT7A; Wnt family member 7A
7477  WNT7B; Wnt family member 7B
7478  WNT8A; Wnt family member 8A
7479  WNT8B; Wnt family member 8B
7483  WNT9A; Wnt family member 9A
7484  WNT9B; Wnt family member 9B
80326  WNT10A; Wnt family member 10A
7480  WNT10B; Wnt family member 10B
51384  WNT16; Wnt family member 16
8321  FZD1; frizzled class receptor 1
2535  FZD2; frizzled class receptor 2
7976  FZD3; frizzled class receptor 3
8322  FZD4; frizzled class receptor 4
7855  FZD5; frizzled class receptor 5
8323  FZD6; frizzled class receptor 6
8324  FZD7; frizzled class receptor 7
8325  FZD8; frizzled class receptor 8
8326  FZD9; frizzled class receptor 9
11211  FZD10; frizzled class receptor 10
4040  LRP6; LDL receptor related protein 6
1855  DVL1; dishevelled segment polarity protein 1
1856  DVL2; dishevelled segment polarity protein 2
1857  DVL3; dishevelled segment polarity protein 3
10023  FRAT1; FRAT1, WNT signaling pathway regulator
23401  FRAT2; FRAT2, WNT signaling pathway regulator
2932  GSK3B; glycogen synthase kinase 3 beta
8312  AXIN1; axin 1
8313  AXIN2; axin 2
324  APC; APC, WNT signaling pathway regulator
1499  CTNNB1; catenin beta 1
6932  TCF7; transcription factor 7
83439  TCF7L1; transcription factor 7 like 1
6934  TCF7L2; transcription factor 7 like 2
51176  LEF1; lymphoid enhancer binding factor 1
4609  MYC; MYC proto-oncogene, bHLH transcription factor
595  CCND1; cyclin D1
Variant
4040v1 (LRP6*)  LRP6 overexpression
Reference
PMID:21898546
  Authors
King TD, Suto MJ, Li Y
  Title
The Wnt/beta-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.
  Journal
J Cell Biochem 113:13-8 (2012)
DOI:10.1002/jcb.23350
Reference
PMID:26040571
  Authors
Jamdade VS, Sethi N, Mundhe NA, Kumar P, Lahkar M, Sinha N
  Title
Therapeutic targets of triple-negative breast cancer: a review.
  Journal
Br J Pharmacol 172:4228-37 (2015)
DOI:10.1111/bph.13211
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