KEGG   NETWORK: N00065Help
Entry
N00065                      Network                                

Name
Mutation-inactivated SMAD2 to TGF-beta signaling pathway
Definition
(TGFBR2+TGFBR1) // (SMAD2*,SMAD3)
  Expanded
(7048+7046) // (4087v1,4088)
Class
nt06218 TGFB signaling
nt06260 Colorectal cancer
Type
Variant
Pathway
hsa05210  Colorectal cancer
Disease
H00020  Colorectal cancer
Gene
7048  TGFBR2; transforming growth factor beta receptor 2
7046  TGFBR1; transforming growth factor beta receptor 1
4087  SMAD2; SMAD family member 2
4088  SMAD3; SMAD family member 3
Variant
4087v1  SMAD2 mutation
Reference
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Reference
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
  Authors
Blobe GC, Schiemann WP, Lodish HF
  Title
Role of transforming growth factor beta in human disease.
  Journal
N Engl J Med 342:1350-8 (2000)
DOI:10.1056/NEJM200005043421807
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