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Entry
N00067                      Network                                

Name
Deleted p14(ARF) to p21-cell cycle G1/S
Definition
CDKN2A* // MDM2 -| TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F
  Expanded
1029v1 // 4193 -| 7157 => 1026 -| ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06265 Bladder cancer
nt06268 Melanoma
nt06273 Glioma
nt06276 Chronic myeloid leukemia
Type
Variant
Pathway
hsa05220  Chronic myeloid leukemia
hsa05219  Bladder cancer
hsa05214  Glioma
hsa05218  Melanoma
Disease
H00004  Chronic myeloid leukemia
H00022  Bladder cancer
H00042  Glioma
H00038  Melanoma
Gene
1029  CDKN2A; cyclin dependent kinase inhibitor 2A
4193  MDM2; MDM2 proto-oncogene
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
1029v1  CDKN2A deletion
Reference
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
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