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Entry
N00068                      Network                                

Name
Amplified MDM2 to p21-cell cycle G1/S
Definition
MDM2* -| TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F
  Expanded
4193v1 -| 7157 => 1026 -| ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06273 Glioma
Type
Variant
Pathway
hsa05214  Glioma
Disease
H00042  Glioma
Gene
4193  MDM2; MDM2 proto-oncogene
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
4193v1  MDM2 amplification
Reference
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
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