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Entry
N00069                      Network                                

Name
p16-Cell cycle G1/S
Definition
CDKN2A -| (CCND+CDK4/6) -> RB1 // E2F
  Expanded
1029 -| ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06262 Pancreatic cancer
nt06265 Bladder cancer
nt06268 Melanoma
nt06273 Glioma
nt06130 Cell cycle (virus)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
1029  CDKN2A; cyclin dependent kinase inhibitor 2A
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Reference
  Authors
Neganova I, Lako M
  Title
G1 to S phase cell cycle transition in somatic and embryonic stem cells.
  Journal
J Anat 213:30-44 (2008)
DOI:10.1111/j.1469-7580.2008.00931.x
Reference
  Authors
Ohtani N, Yamakoshi K, Takahashi A, Hara E
  Title
The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression.
  Journal
J Med Invest 51:146-53 (2004)
DOI:10.2152/jmi.51.146
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