KEGG   NETWORK: N00072Help
Entry
N00072                      Network                                

Name
Amplified CDK4 to cell cycle G1/S
Definition
(CCND+CDK4*) -> RB1 // E2F
  Expanded
((595,894,896)+1019v1) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06273 Glioma
Type
Variant
Pathway
hsa05214  Glioma
Disease
H00042  Glioma
Gene
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
1019v1  CDK4 amplification
Reference
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
LinkDB All DBs

DBGET integrated database retrieval system