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Entry
N00073                      Network                                

Name
Mutation-activated CDK4 to cell cycle G1/S
Definition
(CCND+CDK4*) -> RB1 // E2F
  Expanded
((595,894,896)+1019v2) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06268 Melanoma
Type
Variant
Pathway
hsa05218  Melanoma
Disease
H00038  Melanoma
Gene
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
1019v2  CDK4 mutation
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
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