KEGG   NETWORK: N00074Help
Entry
N00074                      Network                                

Name
Loss of RB1 to cell cycle G1/S
Definition
RB1* // E2F
  Expanded
5925v1 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06263 Hepatocellular carcinoma
nt06265 Bladder cancer
nt06267 Small cell lung cancer
nt06273 Glioma
nt06276 Chronic myeloid leukemia
Type
Variant
Pathway
hsa05214  Glioma
hsa05220  Chronic myeloid leukemia
hsa05225  Hepatocellular carcinoma
hsa05219  Bladder cancer
hsa05222  Small cell lung cancer
Disease
H00042  Glioma
H00004  Chronic myeloid leukemia
H00048  Hepatocellular carcinoma
H00022  Bladder cancer
H00013  Small cell lung cancer
Gene
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
5925v1  RB1 loss
Reference
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
  Authors
Shiraha H, Yamamoto K, Namba M
  Title
Human hepatocyte carcinogenesis (review).
  Journal
Int J Oncol 42:1133-8 (2013)
DOI:10.3892/ijo.2013.1829
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