KEGG   NETWORK: N00082Help
Entry
N00082                      Network                                

Name
Loss of NKX3-1 to PI3K signaling pathway
Definition
NKX3-1* // AKT -| BAD
  Expanded
4824v1 // (207,208,10000) -| 572
Class
nt06214 PI3K signaling
nt06272 Prostate cancer
Type
Variant
Pathway
hsa05215  Prostate cancer
Disease
H00024  Prostate cancer
Gene
4824  NKX3-1; NK3 homeobox 1
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Variant
4824v1  NKX3-1 loss
Reference
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
  Authors
Kim MJ, Cardiff RD, Desai N, Banach-Petrosky WA, Parsons R, Shen MM, Abate-Shen C
  Title
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.
  Journal
Proc Natl Acad Sci U S A 99:2884-9 (2002)
DOI:10.1073/pnas.042688999
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