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Entry
N00086                      Network                                

Name
Notch signaling pathway
Definition
(DLL,JAG) -> NOTCH => (HES1,HEY1)
  Expanded
(28514,10683,54567,182,3714) -> (4851,4853,4854,4855) => (3280,23462)
Class
nt06216 NOTCH signaling
nt06270 Breast cancer
nt06116 NOTCH signaling (virus)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04330  Notch signaling pathway
Gene
28514  DLL1; delta like canonical Notch ligand 1
10683  DLL3; delta like canonical Notch ligand 3
54567  DLL4; delta like canonical Notch ligand 4
182  JAG1; jagged 1
3714  JAG2; jagged 2
4851  NOTCH1; notch 1
4853  NOTCH2; notch 2
4854  NOTCH3; notch 3
4855  NOTCH4; notch 4
3280  HES1; hes family bHLH transcription factor 1
23462  HEY1; hes related family bHLH transcription factor with YRPW motif 1
Reference
  Authors
Ranganathan P, Weaver KL, Capobianco AJ
  Title
Notch signalling in solid tumours: a little bit of everything but not all the time.
  Journal
Nat Rev Cancer 11:338-51 (2011)
DOI:10.1038/nrc3035
Reference
  Authors
Kopan R, Ilagan MX
  Title
The canonical Notch signaling pathway: unfolding the activation mechanism.
  Journal
Cell 137:216-33 (2009)
DOI:10.1016/j.cell.2009.03.045
Reference
  Authors
Hori K, Sen A, Artavanis-Tsakonas S
  Title
Notch signaling at a glance.
  Journal
J Cell Sci 126:2135-40 (2013)
DOI:10.1242/jcs.127308
Reference
  Authors
Bray SJ
  Title
Notch signalling: a simple pathway becomes complex.
  Journal
Nat Rev Mol Cell Biol 7:678-89 (2006)
DOI:10.1038/nrm2009
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