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Entry
N00088                      Network                                

Name
Amplified MYC to p15-cell cycle G1/S
Definition
(MYC*+MAX) -| ZBTB17 => CDKN2B -| (CCND+CDK4/6) -> RB1 // E2F
  Expanded
(4609v1+4149) -| 7709 => 1030 -| ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06267 Small cell lung cancer
Type
Variant
Pathway
hsa05222  Small cell lung cancer
Disease
H00013  Small cell lung cancer
Gene
4609  MYC; MYC proto-oncogene, bHLH transcription factor
4149  MAX; MYC associated factor X
9063  PIAS2; protein inhibitor of activated STAT 2
1030  CDKN2B; cyclin dependent kinase inhibitor 2B
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
4609v1  MYC amplification
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
  Authors
Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Moroy T, Bartek J, Massague J, Hanel F, Eilers M
  Title
Repression of p15INK4b expression by Myc through association with Miz-1.
  Journal
Nat Cell Biol 3:392-9 (2001)
DOI:10.1038/35070076
Reference
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
  Authors
Zajac-Kaye M
  Title
Myc oncogene: a key component in cell cycle regulation and its implication for lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S43-6 (2001)
DOI:10.1016/S0169-5002(01)00343-9
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