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Entry
N00091                      Network                                

Name
p27-Cell cycle G1/S
Definition
(SCF+SKP2) -| CDKN1B -| ((CCNA,CCNE)+CDK2) -> RB1 // E2F
  Expanded
(6500+8454+9978+6502) -| 1027 -| ((890,8900,898,9134)+1017) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06261 Gastric cancer
nt06267 Small cell lung cancer
nt06272 Prostate cancer
nt06130 Cell cycle (virus)
nt06165 Epstein-Barr virus (EBV)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
6500  SKP1; S-phase kinase associated protein 1
8454  CUL1; cullin 1
9978  RBX1; ring-box 1
6502  SKP2; S-phase kinase associated protein 2
1027  CDKN1B; cyclin dependent kinase inhibitor 1B
890  CCNA2; cyclin A2
8900  CCNA1; cyclin A1
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
1017  CDK2; cyclin dependent kinase 2
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Reference
  Authors
Wang IC, Chen YJ, Hughes D, Petrovic V, Major ML, Park HJ, Tan Y, Ackerson T, Costa RH
  Title
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase.
  Journal
Mol Cell Biol 25:10875-94 (2005)
DOI:10.1128/MCB.25.24.10875-10894.2005
Reference
  Authors
Penin RM, Fernandez-Figueras MT, Puig L, Rex J, Ferrandiz C, Ariza A
  Title
Over-expression of p45(SKP2) in Kaposi's sarcoma correlates with higher tumor stage and extracutaneous involvement but is not directly related to p27(KIP1) down-regulation.
  Journal
Mod Pathol 15:1227-35 (2002)
DOI:10.1097/01.MP.0000036589.99516.D6
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