KEGG   NETWORK: N00095Help
Entry
N00095                      Network                                

Name
ERBB2-overexpression to EGF-Jak-STAT signaling pathway
Definition
EGF -> (ERBB2*+EGFR) -> JAK1 -> STAT1/3 => VEGFA
  Expanded
1950 -> (2064v1+1956) -> 3716 -> (6772,6774) => 7422
Class
nt06219 JAK-STAT signaling
nt06262 Pancreatic cancer
Type
Variant
Pathway
hsa05212  Pancreatic cancer
Disease
H00019  Pancreatic cancer
Gene
1950  EGF; epidermal growth factor
2064  ERBB2; erb-b2 receptor tyrosine kinase 2
1956  EGFR; epidermal growth factor receptor
3716  JAK1; Janus kinase 1
6772  STAT1; signal transducer and activator of transcription 1
6774  STAT3; signal transducer and activator of transcription 3
7422  VEGFA; vascular endothelial growth factor A
Variant
2064v1  ERBB2 overexpression
Reference
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
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