KEGG   NETWORK: N00103Help
Entry
N00103                      Network                                

Name
EGF-EGFR-RAS-RalGDS signaling pathway
Definition
EGF -> EGFR -> GRB2 -> SOS -> RAS -> RALGDS -> RAL
  Expanded
1950 -> 1956 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> 5900 -> (5898,5899)
Class
nt06213 Other RAS signaling
nt06260 Colorectal cancer
nt06262 Pancreatic cancer
Type
Reference
Pathway
hsa04014  Ras signaling pathway
Gene
1950  EGF; epidermal growth factor
1956  EGFR; epidermal growth factor receptor
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
5900  RALGDS; ral guanine nucleotide dissociation stimulator
5898  RALA; RAS like proto-oncogene A
5899  RALB; RAS like proto-oncogene B
Reference
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
  Authors
Normanno N, Tejpar S, Morgillo F, De Luca A, Van Cutsem E, Ciardiello F
  Title
Implications for KRAS status and EGFR-targeted therapies in metastatic CRC.
  Journal
Nat Rev Clin Oncol 6:519-27 (2009)
DOI:10.1038/nrclinonc.2009.111
Reference
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
LinkDB All DBs

DBGET integrated database retrieval system