KEGG   NETWORK: N00104
Entry
N00104                      Network                                

Name
Mutation-activated KRAS to RalGDS signaling pathway
Definition
KRAS* -> RALGDS -> RAL
  Expanded
3845v1 -> 5900 -> (5898,5899)
Class
nt06213 Other RAS signaling
nt06260 Colorectal cancer
nt06262 Pancreatic cancer
Type
Variant
Pathway
hsa05210  Colorectal cancer
hsa05212  Pancreatic cancer
Disease
H00020  Colorectal cancer
H00019  Pancreatic cancer
Gene
3845  KRAS; KRAS proto-oncogene, GTPase
5900  RALGDS; ral guanine nucleotide dissociation stimulator
5898  RALA; RAS like proto-oncogene A
5899  RALB; RAS like proto-oncogene B
Variant
3845v1 (KRAS*)  KRAS mutation
Reference
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
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