KEGG   NETWORK: N00105Help
Entry
N00105                      Network                                

Name
EML4-ALK fusion kinase to Jak-STAT signaling pathway
Definition
EML4-ALK -> JAK3 -> STAT3,STAT5
  Expanded
(238v1,238v2) -> 3718 -> (6774,6776,6777)
Class
nt06219 JAK-STAT signaling
nt06266 Non-small cell lung cancer
Type
Variant
Pathway
hsa05223  Non-small cell lung cancer
Disease
H00014  Non-small cell lung cancer
Gene
238  ALK; ALK receptor tyrosine kinase
3718  JAK3; Janus kinase 3
6774  STAT3; signal transducer and activator of transcription 3
6776  STAT5A; signal transducer and activator of transcription 5A
6777  STAT5B; signal transducer and activator of transcription 5B
Variant
238v1  EML4-ALK fusion
238v2  First generation TKI-resistant ALK1 mutation
Reference
  Authors
Roskoski R Jr
  Title
Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition.
  Journal
Pharmacol Res 68:68-94 (2013)
DOI:10.1016/j.phrs.2012.11.007
Reference
  Authors
Solomon B, Wilner KD, Shaw AT
  Title
Current status of targeted therapy for anaplastic lymphoma kinase-rearranged non-small cell lung cancer.
  Journal
Clin Pharmacol Ther 95:15-23 (2014)
DOI:10.1038/clpt.2013.200
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