KEGG   NETWORK: N00107Help
Entry
N00107                      Network                                

Name
EVI-1 overexpression to TGF-beta signaling pathway
Definition
EVI1* -| SMAD3 -- SMAD4
  Expanded
2122v1 -| 4088 -- 4089
Class
nt06218 TGFB signaling
nt06276 Chronic myeloid leukemia
Type
Variant
Pathway
hsa05220  Chronic myeloid leukemia
Disease
H00004  Chronic myeloid leukemia
Gene
2122  MECOM; MDS1 and EVI1 complex locus
4088  SMAD3; SMAD family member 3
4089  SMAD4; SMAD family member 4
Variant
2122v1  EVI1 overexpression
Reference
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
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