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Entry
N00110                      Network                                

Name
PLZF-RARA fusion to transcriptional activtion
Definition
PLZF-RARA => (JUP,CCNA1,MYC)
  Expanded
7704v1 => (3728,8900,4609)
Class
nt06240 Transcription
nt06275 Acute myeloid leukemia
Type
Variant
Pathway
hsa05221  Acute myeloid leukemia
hsa05202  Transcriptional misregulation in cancer
Disease
H00003  Acute myeloid leukemia
Gene
7704  ZBTB16; zinc finger and BTB domain containing 16
3728  JUP; junction plakoglobin
8900  CCNA1; cyclin A1
4609  MYC; MYC proto-oncogene, bHLH transcription factor
Variant
7704v1  PLZF-RARA fusion
Reference
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
  Authors
Muller C, Yang R, Park DJ, Serve H, Berdel WE, Koeffler HP
  Title
The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia.
  Journal
Blood 96:3894-9 (2000)
Reference
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
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