KEGG   NETWORK: N00111Help
Entry
N00111                      Network                                

Name
AML1-ETO fusion to CEBPA-mediated transcription
Definition
AML1-ETO -| CEBPA => PER2
  Expanded
861v2 -| 1050 => 8864
Class
nt06240 Transcription
nt06275 Acute myeloid leukemia
Type
Variant
Pathway
hsa05221  Acute myeloid leukemia
hsa05202  Transcriptional misregulation in cancer
Disease
H00003  Acute myeloid leukemia
Gene
861  RUNX1; runt related transcription factor 1
1050  CEBPA; CCAAT/enhancer binding protein alpha
8864  PER2; period circadian clock 2
Variant
861v2  AML1-ETO fusion
Reference
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
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