KEGG   NETWORK: N00116Help
Entry
N00116                      Network                                

Name
Mutation-inactivated RUNX1 to transcription
Definition
RUNX1* // (CSF1R,MPO,CSF2,IL3)
  Expanded
861v3 // (1436,4353,1437,3562)
Class
nt06240 Transcription
nt06275 Acute myeloid leukemia
Type
Variant
Pathway
hsa05221  Acute myeloid leukemia
hsa05202  Transcriptional misregulation in cancer
Disease
H00003  Acute myeloid leukemia
Gene
861  RUNX1; runt related transcription factor 1
1436  CSF1R; colony stimulating factor 1 receptor
4353  MPO; myeloperoxidase
1437  CSF2; colony stimulating factor 2
3562  IL3; interleukin 3
Variant
861v3  AML1 mutation
Reference
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
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