NETWORK: N00120
Entry
N00120 Network
Name
MLL-ENL fusion to transcriptional activation
Definition
MLL-ENL => (MEIS1,
HOXA9,
HOXA10,
HOXA11,
SIX1,
SIX4,
EYA1,
CDKN2C,
HPGD,
GRIA3,
FUT8)
Expanded
(4297v2,
4298v1) => (4211,
3205,
3206,
3207,
6495,
51804,
2138,
1031,
3248,
2892,
2530)
Class
nt06240
Transcription
Type
Variant
Pathway
hsa05202
Transcriptional misregulation in cancer
Disease
H00002
T-cell acute lymphoblastic leukemia
Gene
4297
KMT2A; lysine methyltransferase 2A
4298
MLLT1; MLLT1, super elongation complex subunit
4211
MEIS1; Meis homeobox 1
3205
HOXA9; homeobox A9
3206
HOXA10; homeobox A10
3207
HOXA11; homeobox A11
6495
SIX1; SIX homeobox 1
51804
SIX4; SIX homeobox 4
2138
EYA1; EYA transcriptional coactivator and phosphatase 1
1031
CDKN2C; cyclin dependent kinase inhibitor 2C
3248
HPGD; hydroxyprostaglandin dehydrogenase 15-(NAD)
2892
GRIA3; glutamate ionotropic receptor AMPA type subunit 3
2530
FUT8; fucosyltransferase 8
Variant
4297v2
MLL-ENL fusion
4298v1
MLL-ENL fusion
Reference
PMID:
21518926
Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
Journal
Blood 117:6895-905 (2011)
DOI:
10.1182/blood-2010-12-324699
Reference
PMID:
14701735
Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
Journal
Mol Cell Biol 24:617-28 (2004)
DOI:
10.1128/MCB.24.2.617-628.2004
Reference
PMID:
8640717
Authors
Horstmann M, Argyriou-Tirita A, Borkhardt A, Kabisch H, Kapaun P, Winkler K, Haas OA
Title
MLL/ENL fusion in congenital acute lymphoblastic leukemia with a unique t(11;18;19).
Journal
Cancer Genet Cytogenet 88:103-9 (1996)
DOI:
10.1016/0165-4608(95)00276-6
LinkDB
DBGET
integrated database retrieval system
