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Entry
N00120                      Network                                

Name
MLL-ENL fusion to transcriptional activation
Definition
MLL-ENL => (MEIS1,HOXA9,HOXA10,HOXA11,SIX1,SIX4,EYA1,CDKN2C,HPGD,GRIA3,FUT8)
  Expanded
(4297v2,4298v1) => (4211,3205,3206,3207,6495,51804,2138,1031,3248,2892,2530)
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00002  T-cell acute lymphoblastic leukemia
Gene
4297  KMT2A; lysine methyltransferase 2A
4298  MLLT1; MLLT1, super elongation complex subunit
4211  MEIS1; Meis homeobox 1
3205  HOXA9; homeobox A9
3206  HOXA10; homeobox A10
3207  HOXA11; homeobox A11
6495  SIX1; SIX homeobox 1
51804  SIX4; SIX homeobox 4
2138  EYA1; EYA transcriptional coactivator and phosphatase 1
1031  CDKN2C; cyclin dependent kinase inhibitor 2C
3248  HPGD; hydroxyprostaglandin dehydrogenase 15-(NAD)
2892  GRIA3; glutamate ionotropic receptor AMPA type subunit 3
2530  FUT8; fucosyltransferase 8
Variant
4297v2  MLL-ENL fusion
4298v1  MLL-ENL fusion
Reference
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:8640717
  Authors
Horstmann M, Argyriou-Tirita A, Borkhardt A, Kabisch H, Kapaun P, Winkler K, Haas OA
  Title
MLL/ENL fusion in congenital acute lymphoblastic leukemia with a unique t(11;18;19).
  Journal
Cancer Genet Cytogenet 88:103-9 (1996)
DOI:10.1016/0165-4608(95)00276-6
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