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Entry
N00123                      Network                                

Name
Amplified REL to transcription
Definition
REL* => (CCND2,BCL2A1,BIRC3,TRAF1,BCL2L1,CD86,CD40)
  Expanded
5966v1 => (894,597,330,7185,598,942,958)
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00007  Hodgkin lymphoma
Gene
5966  REL; REL proto-oncogene, NF-kB subunit
894  CCND2; cyclin D2
597  BCL2A1; BCL2 related protein A1
330  BIRC3; baculoviral IAP repeat containing 3
7185  TRAF1; TNF receptor associated factor 1
598  BCL2L1; BCL2 like 1
942  CD86; CD86 molecule
958  CD40; CD40 molecule
Variant
5966v1  REL amplification
Reference
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
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