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Entry
N00124                      Network                                

Name
IGH-MAF fusion to transcriptional activation
Definition
IGH-MAF => (CCND2,ITGB7)
  Expanded
4094v1 => (894,3695)
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00010  Multiple myeloma
Gene
4094  MAF; MAF bZIP transcription factor
894  CCND2; cyclin D2
3695  ITGB7; integrin subunit beta 7
Variant
4094v1  IGH-MAF fusion
Reference
  Authors
Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM
  Title
Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
  Journal
Cancer Cell 5:191-9 (2004)
DOI:10.1016/S1535-6108(04)00019-4
Reference
PMID:9616139
  Authors
Chesi M, Bergsagel PL, Shonukan OO, Martelli ML, Brents LA, Chen T, Schrock E, Ried T, Kuehl WM
  Title
Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma.
  Journal
Blood 91:4457-63 (1998)
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