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Entry
N00125                      Network                                

Name
IGH-MMSET fusion to transcriptional activation
Definition
IGH-MMSET -> H3 => CCND2
  Expanded
7468v1 -> (126961,3020,3021,333932,440093,653604,8290,8350,8351,8352,8353,8354,8355,8356,8357,8358,8968) => 894
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00010  Multiple myeloma
Gene
7468  NSD2; nuclear receptor binding SET domain protein 2
126961  HIST2H3C; histone cluster 2 H3 family member c
3020  H3F3A; H3 histone family member 3A
3021  H3F3B; H3 histone family member 3B
333932  HIST2H3A; histone cluster 2 H3 family member a
440093  H3F3C; H3 histone family member 3C
653604  HIST2H3D; histone cluster 2 H3 family member d
8290  HIST3H3; histone cluster 3 H3
8350  HIST1H3A; histone cluster 1 H3 family member a
8351  HIST1H3D; histone cluster 1 H3 family member d
8352  HIST1H3C; histone cluster 1 H3 family member c
8353  HIST1H3E; histone cluster 1 H3 family member e
8354  HIST1H3I; histone cluster 1 H3 family member i
8355  HIST1H3G; histone cluster 1 H3 family member g
8356  HIST1H3J; histone cluster 1 H3 family member j
8357  HIST1H3H; histone cluster 1 H3 family member h
8358  HIST1H3B; histone cluster 1 H3 family member b
8968  HIST1H3F; histone cluster 1 H3 family member f
894  CCND2; cyclin D2
Variant
7468v1  IGH-MMSET fusion
Reference
  Authors
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
  Title
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
  Journal
Blood 117:211-20 (2011)
DOI:10.1182/blood-2010-07-298349
Reference
  Authors
Brito JL, Walker B, Jenner M, Dickens NJ, Brown NJ, Ross FM, Avramidou A, Irving JA, Gonzalez D, Davies FE, Morgan GJ
  Title
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
  Journal
Haematologica 94:78-86 (2009)
DOI:10.3324/haematol.13426
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